[在通过膜过滤法检测微生物污染时硫酸镁对四环素的灭活作用]
[Tetracycline inactivation by magnesium sulfate in testing for microbial contamination by the membrane filtration method].
作者信息
Klimova N E, Grigor'eva V M
出版信息
Antibiotiki. 1977;22(2):117-20.
PMID:404955
Abstract
It was shown that the residual amounts of tetracyclines adsorbed on membrane filters may be inactivated by addition of 2M magnesium sulphate solution to the agar for placing the filters after filtration. The antibiotic inactivation increases the possibilities of the test for antibiotic sensitivity of the microflora present in the drugs and may be used in determination of microbial dissmination of non-injection tetracyclines.
摘要
结果表明，对于过滤后放置在琼脂中的膜滤器，通过向琼脂中加入2M硫酸镁溶液可使吸附在膜滤器上的四环素残留量失活。抗生素失活增加了检测药物中存在的微生物对抗生素敏感性的可能性，可用于测定非注射用四环素的微生物扩散情况。
相似文献
1
2
3
[Comparison of the efficacy of 3 methods of testing for the sterility of eye ointments with antibiotics].[三种含抗生素眼膏无菌检查方法的效果比较]
Antibiotiki. 1976 Feb;21(2):118-22.
4
[Sensitivity to doxycycline (vibramycin) of the microflora isolated from the patients in a therapeutic clinic].
Antibiotiki. 1975 Aug;20(8):714-7.
5
[Characteristics of determining the microbial contamination of penicillin series antibiotic powders and tablets].[青霉素类抗生素粉针剂及片剂微生物污染测定的特点]
Antibiotiki. 1977 Mar;22(3):208-11.
6
7
[Determination of the microbial contamination of tablets of tetracycline series antibiotics].[四环素类抗生素片剂微生物污染的测定]
Antibiotiki. 1978 Mar;23(3):219-22.
8
Use of molecularly imprinted polymers from a mixture of tetracycline and its degradation products to produce affinity membranes for the removal of tetracycline from water.利用四环素及其降解产物的混合物制备分子印迹聚合物，以生产用于从水中去除四环素的亲和膜。
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Nov 25;811(2):191-200. doi: 10.1016/j.jchromb.2004.08.044.
9
In vitro studies of the loss of antibacterial activity of oxytetracycline in presence of Ca(II) or Mg(II) ions.
Arzneimittelforschung. 1996 Jul;46(7):701-4.
10
[Determination of antibiotic chemicals using microbiological tests: evaluation of the limits of sensitivity].[使用微生物学检测法测定抗生素化学物质：灵敏度限度评估]
Boll Soc Ital Biol Sper. 1991 Jun;67(6):561-8.
Zotero 插件