Kajal Navdeep, Raj Amar, Tatikonda Rajendhraprasad, Lundell Jan, Haukka Matti
Department of Chemistry, University of Jyväskylä, P. O. Box 35, Jyväskylä, FI-40014, Finland.
Nanoscience Center, Department of Chemistry, University of Jyväskylä, P. O. Box 35, Jyväskylä, FI-40014, Finland.
Chempluschem. 2025 Aug;90(8):e202400687. doi: 10.1002/cplu.202400687. Epub 2025 Jun 29.
Triphenylene derivatives 3PY (2,3,6,7,10,11-hexa(pyridine-3-yl)triphenylene) and 4PY (2,3,6,7,10,11-hexa(pyridine-4-yl)triphenylene) are synthesized using a Suzuki-Miyaura coupling protocol and evaluated as potent chemosensors for the detection of diclofenac in solution phase. Screening against various commonly used nonsteroidal antiinflammatory drugs and hormones demonstrates that the derivatives are selective for diclofenac. The fluorescence quenching mechanism is attributed to the inner filter effect because of the overlap between the UV-vis absorption spectrum of diclofenac and the excitation spectra of triphenylene derivatives. They can sense diclofenac with a low limit of detection of 1.18 μM, offering a simple and cost-effective method. Moreover, the practicability and applicability of the proposed sensor are confirmed in the lake water with reliable recovery and precision.
使用铃木-宫浦偶联方案合成了三亚苯衍生物3PY（2,3,6,7,10,11-六（吡啶-3-基）三亚苯）和4PY（2,3,6,7,10,11-六（吡啶-4-基）三亚苯），并将其评估为用于检测溶液相中双氯芬酸的高效化学传感器。针对各种常用非甾体抗炎药和激素进行的筛选表明，这些衍生物对双氯芬酸具有选择性。荧光猝灭机制归因于内滤效应，这是由于双氯芬酸的紫外-可见吸收光谱与三亚苯衍生物的激发光谱存在重叠。它们能够以1.18μM的低检测限检测双氯芬酸，提供了一种简单且经济高效的方法。此外，所提出的传感器在湖水中的实用性和适用性得到了证实，回收率和精密度可靠。
