Yang Xinge, Li Keke, Zhang Yimin, Sun Ruizhe, Yu Jingjing
School of Sport Science, Beijing Sports University, Beijing, China.
Key Laboratory of Sports and Physical Health, Ministry of Education, Beijing, China.
Psychiatry Clin Psychopharmacol. 2025 Apr 16;35(2):185-197. doi: 10.5152/pcp.2025.241016. eCollection 2025 Jun.
With the rapid acceleration of global aging, the prevalence of Alzheimer's disease (AD) continues to rise, exerting a profound impact on elderly individuals' physical health, lifestyle, and quality of life. Exercise has demonstrated significant research value and broad application potential in AD as a non-pharmacological preventive and therapeutic approach. This study aims to provide a bibliometric and visual analysis of research related to exercise and AD over the past decade. It seeks to identify research hotspots and development trends, explore the layers of research on exercise's impact on AD, and clarify its preventive effects and molecular mechanisms. The Web of Science Core Collection database was used as the data source for this study. A comprehensive search was conducted using the topic "exercise for Alzheimer's disease," covering the period from January 1, 2014, to August 31, 2024. CiteSpace and Python were employed to perform bibliometric and visual analyses on these publications, including assessments of publication trends, keyword co-occurrence, clustering analysis, timeline analysis, burst detection analysis, and the distribution and growth trends of molecular mechanisms related to exercise and AD. 1. Annual publication trends: 6134 articles were included in the analysis. The number of publications on exercise and AD increased steadily from 2014 to 2024 ( = 53.23, < .001). 2. Keyword co-occurrence and clustering analysis: research on exercise and AD primarily focuses on themes related to cognitive decline, risk factors, exercise-induced energy metabolism, exercise intensity, and molecular mechanisms. 3. Keyword timeline and burst analysis: epidemiological and clinical studies maintained high activity levels in the early and mid-stages of the research timeline, whereas molecular-level studies exhibited increased activity in the later stages. 4. Molecular mechanisms distribution: analysis of molecular mechanisms reveals that amyloid-beta deposition and oxidative stress remain the predominant research areas. Meanwhile, research on neuroinflammation, brain-derived neurotrophic factor (BDNF), Tau pathology, and other related mechanisms has been further explored. The findings demonstrate a progressive shift in research focus from general epidemiological patterns to more in-depth investigations of molecular biological mechanisms. Exercise has been shown to play a preventive role at the clinical level by improving cognitive function and mitigating risk factors and at the molecular level by modulating key pathological mechanisms, including β-amyloid deposition, oxidative stress, BDNF, tau pathology, and others. Through the coordinated regulation of multiple targets and pathways, exercise exerts a neuroprotective effect against AD.
随着全球老龄化的迅速加剧，阿尔茨海默病（AD）的患病率持续上升，对老年人的身体健康、生活方式和生活质量产生了深远影响。作为一种非药物预防和治疗方法，运动在AD研究中已显示出重要的研究价值和广泛的应用潜力。本研究旨在对过去十年中与运动和AD相关的研究进行文献计量和可视化分析。旨在识别研究热点和发展趋势，探索运动对AD影响的研究层次，阐明其预防作用和分子机制。本研究以Web of Science核心合集数据库作为数据源。使用主题“阿尔茨海默病的运动”进行全面检索，涵盖2014年1月1日至2024年8月31日期间。使用CiteSpace和Python对这些出版物进行文献计量和可视化分析，包括对出版趋势、关键词共现、聚类分析、时间线分析、突发检测分析以及与运动和AD相关的分子机制的分布和增长趋势的评估。1.年度出版趋势：分析纳入6134篇文章。2014年至2024年期间，关于运动和AD的出版物数量稳步增加（ = 53.23， <.001）。2.关键词共现和聚类分析：运动和AD的研究主要集中在与认知衰退、危险因素、运动诱导的能量代谢、运动强度和分子机制相关的主题上。3.关键词时间线和突发分析：在研究时间线的早期和中期，流行病学和临床研究保持较高的活跃度，而分子水平的研究在后期表现出活跃度增加。4.分子机制分布：分子机制分析表明，淀粉样蛋白-β沉积和氧化应激仍然是主要的研究领域。同时，对神经炎症、脑源性神经营养因子（BDNF）、Tau病理等相关机制的研究也得到了进一步探索。研究结果表明，研究重点从一般流行病学模式逐渐转向对分子生物学机制的更深入研究。运动已被证明在临床水平上通过改善认知功能和减轻危险因素发挥预防作用，在分子水平上通过调节关键病理机制，包括β-淀粉样蛋白沉积、氧化应激、BDNF、tau病理等发挥预防作用。通过对多个靶点和途径的协同调节，运动对AD发挥神经保护作用。
