Kino Junichi, Morimoto Tsubasa, Matsuda Yasuhiro, Honda Masato, Kishimoto Toshifumi, Okada Takashi
Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan.
Department of Psychiatry Akitsukounoike Hospital Gose Japan.
PCN Rep. 2025 Jun 10;4(2):e70137. doi: 10.1002/pcn5.70137. eCollection 2025 Jun.
To examine the effects of a multi-task cognitive activation therapy (MCAT) program combining motor and cognitive tasks in patients with schizophrenia.
Patients with schizophrenia who received psychiatric day care treatment were included in this study. The study used a mirror-image test with a 3-month pre-intervention and intervention period each. MCAT training was conducted twice a week for 12 weeks for a total of 24 sessions. The Brief Assessment of Cognition in Schizophrenia - Japanese version (BACS-J) and Facial Emotional Identified Test were used for the primary outcome; the secondary outcomes included the Positive and Negative Syndrome Scale (PANSS), and the Life Assessment Scale for the Mentally Ill (LASMI).
Thirty-six patients completed the intervention. The -score of the BACS-J before and after the intervention period included verbal memory (-1.98 ± 1.60 before intervention, -1.50 ± 1.41 after intervention, < 0.01, = 0.47) and motor function (-1.47 ± 1.71 before intervention, -0.93 ± 1.50 after intervention, < 0.01, = 0.47). Significant improvement was observed in the composite score (-2.31 ± 1.51 before intervention, -1.92 ± 1.38 after intervention, < 0.01, = 0.52). Significant improvements were also observed on the PANSS comprehensive psychopathology scale and the LASMI interpersonal relationships scale. No other endpoints demonstrated significant improvements. The BACS-J composite score, which was the earliest BACS-J examination, was considered the baseline for all the participants in the moderate and severe groups. The severe group ( = 22) demonstrated significant improvements in the BACS-J verbal memory, composite score, and LASMI interpersonal relationships.
These results suggest that the MCAT may improve cognitive function and interpersonal relationships in patients with schizophrenia and severe or moderate cognitive impairment.
研究多任务认知激活疗法（MCAT），即结合运动和认知任务的疗法，对精神分裂症患者的影响。
本研究纳入了接受精神科日间护理治疗的精神分裂症患者。该研究采用镜像测试，干预前和干预期各为3个月。MCAT训练每周进行两次，共12周，总计24节。主要结局采用精神分裂症认知功能简短评估量表 - 日语版（BACS-J）和面部情绪识别测试；次要结局包括阳性和阴性症状量表（PANSS）以及精神病患者生活评估量表（LASMI）。
36名患者完成了干预。干预期前后BACS-J评分包括言语记忆（干预前为-1.98±1.60，干预后为-1.50±1.41，<0.01，=0.47）和运动功能（干预前为-1.47±1.71，干预后为-0.93±1.50，<0.01，=0.47）。综合评分有显著改善（干预前为-2.31±1.51，干预后为-1.92±1.38，<0.01，=0.52）。PANSS综合精神病理量表和LASMI人际关系量表也有显著改善。其他终点均未显示出显著改善。最早进行的BACS-J综合评分被视为中重度组所有参与者的基线。重度组（=22）在BACS-J言语记忆、综合评分和LASMI人际关系方面有显著改善。
这些结果表明，MCAT可能改善精神分裂症及重度或中度认知障碍患者的认知功能和人际关系。
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