Grobe-Einsler Marcus, Gerdes Anna, Feige Tim, Maas Vivian, Matthews Clare, Mendoza García Alejandro, Comas Fages Laia, Haf Davies Elin, Klockgether Thomas, Falkenburger Björn H
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Center for Neurology, Department of Parkinson's Disease, Sleep and Movement Disorders, University Hospital Bonn, 53127 Bonn, Germany.
J Clin Med. 2025 May 28;14(11):3769. doi: 10.3390/jcm14113769.
: Parkinson Disease (PD) is a progressive neurodegenerative disorder. Current therapeutic trials investigate treatments that can potentially modify the disease course. Testing their efficiency requires outcome assessments that are relevant to patients' daily lives, which include gait and balance. Home-based examinations may enhance patient compliance and, in addition, produce more reliable results by assessing patients more regularly in their familiar surroundings. : The objective of this pilot study was to assess the feasibility of a home-based outcome assessment designed to video record the Timed up and Go (vTUG) test via a study-specific smartphone app for patients with PD. : 28 patients were recruited and asked to perform at home each week a set of three consecutive vTUG tests, over a period of 12 weeks using an app. The videos were subjected to a manual review to ascertain the durations of the individual vTUG phases, as well as to identify any errors or deviations in the setup that might have influenced the result. To evaluate the usability and user-friendliness of the vTUG and app, the System Usability Scale (SUS) and User Experience Questionnaire (UEQ) were administered to patients at the study end. : 19 patients completed the 12-week study, 17 of which recorded 10 videos or more. A total of 706 vTUGs with complete timings were recorded. Random Forest Regression yielded "time to walk up" as the most important segment of the vTUG for predicting the total time. Variance of vTUG total time was significantly higher between weeks than it was between the three consecutive vTUGs at one time point [F(254,23) = 6.50, < 0.001]. The correlation between vTUG total time and UPDRS III total score was weak (r = 0.24). The correlation between vTUG and a derived gait subscore (UPDRS III items 9-13) was moderate (r = 0.59). A linear mixed-effects model revealed a significant effect of patient-reported motion status on vTUG total time. Including additional variables such as UPDRS III gait subscore, footwear and chairs used further improved the model fit. : Assessment of gait and balance by home-based vTUG is feasible. Factors influencing the read-out were identified and could be better controlled for future use and longitudinal trials.
帕金森病（PD）是一种进行性神经退行性疾病。目前的治疗试验正在研究可能改变疾病进程的治疗方法。测试其有效性需要与患者日常生活相关的结果评估，其中包括步态和平衡。基于家庭的检查可能会提高患者的依从性，此外，通过在患者熟悉的环境中更定期地评估患者，可产生更可靠的结果。：本试点研究的目的是评估一种基于家庭的结果评估的可行性，该评估旨在通过一款针对帕金森病患者的特定研究智能手机应用程序对计时起立行走（vTUG）测试进行视频记录。：招募了28名患者，并要求他们在12周的时间内，使用一款应用程序，每周在家中连续进行一组三次vTUG测试。对视频进行人工审查，以确定各个vTUG阶段的持续时间，并识别设置中可能影响结果的任何错误或偏差。为了评估vTUG和应用程序的可用性和用户友好性，在研究结束时向患者发放了系统可用性量表（SUS）和用户体验问卷（UEQ）。：19名患者完成了为期12周的研究，其中17名患者记录了10个或更多视频。共记录了706次具有完整计时的vTUG测试。随机森林回归得出“起身行走时间”是vTUG中预测总时间最重要的部分。vTUG总时间的方差在不同周之间显著高于在某一时刻连续三次vTUG测试之间的方差[F(254,23) = 6.50，< 0.001]。vTUG总时间与UPDRS III总分之间的相关性较弱（r = 0.24）。vTUG与一个派生的步态子评分（UPDRS III项目9 - 13）之间的相关性中等（r = 0.59）。线性混合效应模型显示患者报告的运动状态对vTUG总时间有显著影响。纳入诸如UPDRS III步态子评分、所穿鞋子和使用的椅子等额外变量进一步改善了模型拟合。：通过基于家庭的vTUG评估步态和平衡是可行的。确定了影响读数的因素，以便在未来的使用和纵向试验中能更好地加以控制。
