Yang Ao, Ma Chunyan, Song Qiling, Li Wenhui, Lv Shixuan, Guo Xiuhan, Wang Shisheng, Gao Zhigang, Wang Shuai, Meng Qingwei, Li Yueqing
State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.
Ningbo Institute of Dalian University of Technology, No. 26 Yucai Road, Jiangbei District, Ningbo 315016, China.
Molecules. 2025 May 22;30(11):2263. doi: 10.3390/molecules30112263.
As the proportion of the elderly population increases, there is an urgent need for anti-aging technologies. Since the skin is the most visibly aging organ in the human body, it is crucial to develop active ingredients to slow down skin aging. Currently, identified anti-aging active substances include antioxidants, retinoids, peptides, growth factors, and compounds derived from biofermentation. However, they have limitations such as poor stability, low transdermal permeability, skin irritation, high effective concentrations, slow onset of efficacy, single-action mechanisms, and high production costs. These limitations highlight the necessity of developing new anti-aging technologies that are multifunctional and cause low irritation. This study aimed to investigate the anti-aging effects and mechanisms of fructosazine (FZ) and deoxyfructosazine (DOF) on the skin as well as their potential applications in skincare. The methods included ELISA tests to assess the viability of human dermal fibroblast (NHDF) cells and related factors, and monitoring in Sprague-Dawley (SD) rats. The results showed that FZ promoted cell viability. Both FZ and DOF enhanced the secretion of type I collagen (Col I) and hyaluronic acid (HA), inhibited matrix metalloproteinase-1 (MMP-1), boosted catalase (CAT), and reduced malondialdehyde (MDA), reactive oxygen species (ROS), and β-galactosidase. They also nourished the epidermis and increased fiber content. In conclusion, FZ and DOF can stimulate the production of anti-aging substances, exhibit antioxidant activity, and have potential in skincare.
随着老年人口比例的增加，对抗衰老技术的需求迫切。由于皮肤是人体中最明显衰老的器官，开发减缓皮肤衰老的活性成分至关重要。目前，已确定的抗衰老活性物质包括抗氧化剂、维甲酸、肽、生长因子以及生物发酵衍生的化合物。然而，它们存在稳定性差、透皮渗透率低、皮肤刺激性强、有效浓度高、起效缓慢、作用机制单一以及生产成本高等局限性。这些局限性凸显了开发多功能且低刺激性的新型抗衰老技术的必要性。本研究旨在探讨果糖嗪（FZ）和脱氧果糖嗪（DOF）对皮肤的抗衰老作用及机制，以及它们在护肤品中的潜在应用。方法包括酶联免疫吸附测定（ELISA）试验以评估人真皮成纤维细胞（NHDF）的活力及相关因子，并在斯普拉格 - 道利（SD）大鼠身上进行监测。结果表明，FZ促进细胞活力。FZ和DOF均增强了I型胶原蛋白（Col I）和透明质酸（HA）的分泌，抑制了基质金属蛋白酶 - 1（MMP - 1），提高了过氧化氢酶（CAT）的活性，并降低了丙二醛（MDA）、活性氧（ROS）和β - 半乳糖苷酶的水平。它们还滋养了表皮并增加了纤维含量。总之，FZ和DOF可刺激抗衰老物质的产生，具有抗氧化活性，在护肤品中具有潜在应用价值。
