Kashkina L M, Lavnikova N A
Biull Eksp Biol Med. 1985 Oct;100(10):475-7.
A study was made of migration activity (MA) of peritoneal macrophages of Syrian hamsters after depression of their antitumor natural resistance (NR) induced by injection by heat-inactivated tumor cells. The MA and depression of NR were most pronounced between day 14 and day 20 after inoculation of the animals with inactivated tumor cells of E-1 and STHE-LM8 tumor cells. Inoculation of the hamsters with heat-inactivated tumor cells of another strain (parenteral STHE) did not induce NR depression or enhanced MA of peritoneal macrophages of the treated animals. It is concluded that depression of antitumor NR essential for tumor induction and growth is apparently connected with alterations in the functional activity of macrophages, possibly with their suppressor activity.
对叙利亚仓鼠腹膜巨噬细胞的迁移活性（MA）进行了一项研究，这些仓鼠在通过注射热灭活肿瘤细胞诱导其抗肿瘤天然抵抗力（NR）降低之后。在用E-1和STHE-LM8肿瘤细胞的灭活肿瘤细胞接种动物后的第14天至第20天之间，MA和NR的降低最为明显。用另一株热灭活肿瘤细胞（肠胃外STHE）接种仓鼠，并未诱导所治疗动物腹膜巨噬细胞的NR降低或MA增强。得出的结论是，对肿瘤诱导和生长至关重要的抗肿瘤NR的降低显然与巨噬细胞功能活性的改变有关，可能与其抑制活性有关。
