Maddern G J, Slavotinek J P, Collins P J, Jamieson G G
Clin Physiol. 1985 Oct;5(5):425-32. doi: 10.1111/j.1475-097x.1985.tb00773.x.
Oesophageal emptying of solids and liquids has been assessed in normal subjects using radionuclide techniques. The solid bolus comprised a 10 g disc of cooked minced beef which was labelled with 160 microCi; 99m Tc macro-aggregated albumin (MAA). The liquid bolus consisted of 15 ml of water labelled with 300 microCi; 99m Tc. Studies were performed in the upright and supine positions and repeated after ingestion of 30 ml of 0.1 M HC1 diluted to pH 1.6. Solid and liquid assessments were performed separately with a scintillation camera positioned posteriorly. Subjects were instructed to swallow at the commencement of the test and at 15 s intervals subsequently, until the bolus entered the stomach. Oesophageal emptying in the supine position was significantly slower than emptying in the upright position. This was true for both solid and liquid emptying, in the neutral and in the acidified oesophagus. Emptying of a solid bolus did not appear to be influenced by oesophageal pH. However, emptying of a liquid bolus was significantly slower when the oesophageal pH was acid, for both the supine and upright positions. We conclude that the supine posture delays both liquid and solid oesophageal emptying. The presence of acid in the oesophagus at a pH of 1.6 delayed liquid emptying, but not solid emptying, from the oesophagus.
已使用放射性核素技术对正常受试者的食管固体和液体排空情况进行了评估。固体团块为一片10克的熟牛肉末圆片，用160微居里的99m锝标记的大颗粒白蛋白（MAA）进行标记；液体团块由15毫升用300微居里的99m锝标记的水组成。研究分别在直立位和仰卧位进行，并在摄入30毫升稀释至pH值为1.6的0.1 M盐酸后重复进行。固体和液体评估分别使用位于后方的闪烁相机进行。受试者被指示在测试开始时以及随后每隔15秒吞咽一次，直到团块进入胃内。仰卧位时的食管排空明显慢于直立位时的排空。无论是固体还是液体排空，在中性和酸化食管中都是如此。固体团块的排空似乎不受食管pH值的影响。然而，当食管pH值为酸性时，无论是仰卧位还是直立位，液体团块的排空都明显减慢。我们得出结论，仰卧姿势会延迟液体和固体的食管排空。食管中pH值为1.6的酸性物质的存在会延迟食管中液体的排空，但不会延迟固体的排空。
