Rovituso M, Groenendijk C F, van der Wal E, van Burik W, Ibrahimi A, Rituerto Prieto H, Brown J M C, Weber U, Simeonov Y, Fontana M, Lathouwers D, van Vulpen M, Hoogeman M
Department of Research and Development, Holland Proton Therapy Centre Delft, Delft, The Netherlands.
Department of Radiation Science & Technology, Delft University of Technology, Delft, The Netherlands.
Phys Med. 2025 Feb;130:104883. doi: 10.1016/j.ejmp.2024.104883. Epub 2025 Jan 7.
HollandPTC is an independent outpatient center for proton therapy, scientific research, and education. Patients with different types of cancer are treated with Intensity Modulated Proton Therapy (IMPT). Additionally, the HollandPTC R&D consortium conducts scientific research into the added value and improvements of proton therapy. To this end, HollandPTC created clinical and pre-clinical research facilities including a versatile R&D proton beamline for various types of biologically and technologically oriented research. In this work, we present the characterization of the R&D proton beamline of HollandPTC. Its pencil beam mimics the one used for clinical IMPT, with energy ranging from 70 up to 240 MeV, which has been characterized in terms of shape, size, and intensity. For experiments that need a uniform field in depth and lateral directions, a dual ring passive scattering system has been designed, built, and characterized. With this system, field sizes between 2 × 2 cm and 20 × 20 cm with 98 % uniformity are produced with dose rates ranging from 0.5 Gy/min up to 9 Gy/min. The unique and customized support of the dual ring system allows switching between a pencil beam and a large field in a very simple and fast way, making the HollandPTC R&D proton beam able to support a wide range of different applications.
荷兰质子治疗中心（HollandPTC）是一家独立的门诊质子治疗、科研与教育中心。不同类型癌症患者接受调强质子治疗（IMPT）。此外，荷兰质子治疗中心研发联盟对质子治疗的附加值和改进进行科研。为此，荷兰质子治疗中心创建了临床和临床前研究设施，包括一条多功能研发质子束线，用于各类生物和技术导向研究。在这项工作中，我们展示了荷兰质子治疗中心研发质子束线的特性。其笔形束模拟临床IMPT所用束，能量范围从70到240兆电子伏特，已在形状、尺寸和强度方面进行了特性描述。对于需要在深度和横向方向有均匀射野的实验，设计、建造并表征了一种双环被动散射系统。利用该系统，可产生尺寸在2×2厘米至20×20厘米之间、均匀度达98%的射野，剂量率范围从0.5戈瑞/分钟到9戈瑞/分钟。双环系统独特且定制化的支撑使得能够以非常简单快速的方式在笔形束和大射野之间切换，使荷兰质子治疗中心的研发质子束能够支持广泛的不同应用。
