规律有氧运动对血管功能随衰老的保护作用。
The Protective Role of Regular Aerobic Exercise on Vascular Function with Aging.
作者信息
Craighead Daniel H, Freeberg Kaitlin A, Seals Douglas R
机构信息
Department of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant Street, 354 UCB Clare 114, Boulder, CO 80309.
出版信息
Curr Opin Physiol. 2019 Aug;10:55-63. doi: 10.1016/j.cophys.2019.04.005. Epub 2019 Apr 15.
Aging is the primary risk factor for cardiovascular diseases (CVD), the leading cause of death in developed and developing societies. Much of this age-associated increase in CVD risk is due to arterial dysfunction, characterized by stiffening of the large elastic arteries and endothelial dysfunction. Aerobic exercise is an evidence-based healthy lifestyle strategy for improving arterial function with aging, in part, by suppressing oxidative stress and chronic inflammation. Here, we summarize the effects exercise on arterial function and aging, highlighting recent advancements regarding estrogen-deficient postmenopausal women, cerebrovascular function and healthy lifestyle-inspired interventions that work through similar mechanisms as aerobic exercise.
衰老是心血管疾病（CVD）的主要风险因素，而心血管疾病是发达国家和发展中国家的主要死因。与年龄相关的心血管疾病风险增加，很大程度上是由于动脉功能障碍，其特征是大弹性动脉僵硬和内皮功能障碍。有氧运动是一种基于证据的健康生活方式策略，可改善衰老过程中的动脉功能，部分原因是通过抑制氧化应激和慢性炎症。在此，我们总结运动对动脉功能和衰老的影响，重点介绍关于雌激素缺乏的绝经后女性、脑血管功能以及通过与有氧运动类似机制起作用的健康生活方式干预措施的最新进展。
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