Chen Yiyin, Yang Chengduan, Yang Cheng, Liu Ziqi, Kao Hsiaohan, Chen Hui-Jiuan, Tang Pei
The First People's Hospital of Shuangliu District, West China (Airport) Hospital Sichuan University, Chengdu 610200, China.
School of Rehabilitation, Southern Medical University, Guangzhou 510515, China.
ACS Omega. 2025 Jun 5;10(23):25084-25090. doi: 10.1021/acsomega.5c03352. eCollection 2025 Jun 17.
Blood is enriched with physiological information and could provide valuable references for the diagnosis of various diseases. Influenced by a few factors, including glycolysis, the direct testing of blood may lead to biased results. Healthcare facilities routinely eliminate this bias by centrifugation. However, conventional centrifuges and analysis equipment are large and electricity dependent, limiting their application in less-developed regions. In this work, an integrated blood multiparameter precise sensing system (BMPSS), consisting of a portable manual centrifuge (PMC) and three flex sensor patches (FSPs), was developed for rapid manual centrifugation of blood and detection of glucose, cholesterol, and uric acid levels in postcentrifugation plasma. The test results in solution illustrated that FSPs have favorable linear responsiveness, reproducibility, temporal stability, and selectivity. Experimental results based on rat blood indicated that the PMC has centrifugation results similar to those of commercial centrifuges, and the BMPSS enables adequate centrifugation and precise detection of blood, leading to indications of a wide range of diseases. The results conclusively point to the potential clinical applicability of BMPSS. This work presents the first system that achieves low-cost, portable, electricity-free centrifugation and in situ rapid sample testing; we believe it has promising applications in harsh environments.
血液富含生理信息，可为各种疾病的诊断提供有价值的参考。受包括糖酵解在内的一些因素影响，直接检测血液可能会导致结果有偏差。医疗机构通常通过离心来消除这种偏差。然而，传统离心机和分析设备体积庞大且依赖电力，限制了它们在欠发达地区的应用。在这项工作中，开发了一种集成式血液多参数精确传感系统（BMPSS），它由一个便携式手动离心机（PMC）和三个柔性传感器贴片（FSP）组成，用于对血液进行快速手动离心，并检测离心后血浆中的葡萄糖、胆固醇和尿酸水平。在溶液中的测试结果表明，FSP具有良好的线性响应、重现性、时间稳定性和选择性。基于大鼠血液的实验结果表明，PMC的离心结果与商用离心机相似，并且BMPSS能够对血液进行充分离心和精确检测，从而为多种疾病提供指征。结果明确指出了BMPSS的潜在临床适用性。这项工作展示了首个实现低成本、便携式、无电离心和原位快速样本检测的系统；我们相信它在恶劣环境中具有广阔的应用前景。
