Burdon D W, Ambrose N S, Keighley M R, Youngs D
Infection. 1985;13 Suppl 1:S134-6. doi: 10.1007/BF01644234.
Cefotaxime had an immediate effect on the faecal flora, mainly involving a loss of gram-positive organisms, but also reducing the number of Escherichia coli, Bacteroides spp. and Clostridium spp. There was little effect on the total bacterial counts because of compensatory increases in other species. These changes appear to initiate a period of instability in the composition of the faecal flora lasting for at least 14 days after the administration of cefotaxime. Other third-generation cephalosporins showed a similar prolonged disturbance to the stability of the faecal flora, but there were minor differences from cefotaxime in the bacterial species initially affected.
头孢噻肟对粪便菌群有即刻效应，主要涉及革兰氏阳性菌数量减少，但也降低了大肠杆菌、拟杆菌属和梭菌属的数量。由于其他菌属的代偿性增加，对细菌总数影响不大。这些变化似乎引发了粪便菌群组成的一段不稳定期，在给予头孢噻肟后至少持续14天。其他第三代头孢菌素对粪便菌群稳定性也有类似的长期干扰，但在最初受影响的细菌种类上与头孢噻肟有细微差异。
