Andrade-Mena C E, Orbach-Arbouys S, Mathé G
Immunopharmacology. 1985 Aug;10(1):35-9. doi: 10.1016/0162-3109(85)90057-8.
We evaluated the effects of cycloheximide on two immune responses in the mouse. The data obtained in this series of experiments showed enhancement of the direct splenic plaque-forming cell response to sheep red blood cells when the drug was administered at doses of 25 and 50 mg/kg i.p. and of the delayed type hypersensitivity reaction to oxazolone when cycloheximide was injected at doses of 10, 25 and 50 mg/kg i.p. Depression of these responses was observed when the dose of drug injected was 75 or 100 mg/kg i.p. At a dose of 5 mg/kg cycloheximide had no effect on these immune responses.
我们评估了放线菌酮对小鼠两种免疫反应的影响。在这一系列实验中获得的数据表明，当以25和50毫克/千克的腹腔注射剂量给药时，对绵羊红细胞的直接脾集落形成细胞反应增强；当以10、25和50毫克/千克的腹腔注射剂量注射放线菌酮时，对恶唑酮的迟发型超敏反应增强。当腹腔注射药物剂量为75或100毫克/千克时，观察到这些反应受到抑制。当放线菌酮剂量为5毫克/千克时，对这些免疫反应没有影响。
