电化学合成乙炔亚铜（I）：同时电生成铜离子和催化碱用于点击化学。

Seavill Peter W, Holt Katherine B, Wilden Jonathan D

Department of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK

RSC Adv. 2019 Sep 17;9(50):29300-29304. doi: 10.1039/c9ra06782e. eCollection 2019 Sep 13.

We report an efficient and sustainable electrochemical synthesis of copper(i) acetylides using simultaneous copper oxidation and Hofmann elimination of quaternary ammonium salts. The electrochemically-generated base was also regenerated electrochemically, making it catalytic. A 'Click test' (CuAAC reaction) was performed to assess product purity and an electrochemically-promoted, one-pot CuAAC reaction was performed, which serves as a promising initial demonstration of this approach in a pharmaceutically-relevant reaction.

我们报道了一种高效且可持续的电化学合成炔铜（I）的方法，该方法通过同时进行铜的氧化和季铵盐的霍夫曼消除反应来实现。电化学产生的碱也通过电化学方式进行再生，使其具有催化作用。进行了“点击测试”（铜催化的叠氮化物-炔烃环加成反应）以评估产物纯度，并进行了电化学促进的一锅法铜催化的叠氮化物-炔烃环加成反应，这是该方法在药物相关反应中颇具前景的初步证明。