Kagaya K, Shinoda T, Fukazawa Y
Microbiol Immunol. 1981;25(7):647-54. doi: 10.1111/j.1348-0421.1981.tb00068.x.
Mice immunized with viable C. albicans cells demonstrated a high incidence of cell-mediated and a low incidence of humoral immune response. There was good agreement between the final survival rate of C. albicans infected mice and the rate of simultaneous cell-mediated and humoral immune response acquisition. Immunized mice with positive delayed hypersensitivity (DTH) against C. albicans crude antigen showed significant protection against intravenous challenge with C. albicans. Furthermore, the transfer of immunoglobulins from rabbit anti-C. albicans serum to DTH-positive mice enhanced protection, while it did not protect control mice against a subsequent challenge with C. albicans. These results suggest that cell-mediated immunity plays a major role and humoral immunity a side role in the defense mechanism(s) of C. albicans infected mice.
用活的白色念珠菌细胞免疫的小鼠表现出细胞介导免疫反应的高发生率和体液免疫反应的低发生率。白色念珠菌感染小鼠的最终存活率与同时获得细胞介导免疫和体液免疫反应的速率之间存在良好的一致性。对白色念珠菌粗抗原具有阳性迟发型超敏反应（DTH）的免疫小鼠对白色念珠菌静脉内攻击表现出显著的保护作用。此外，将兔抗白色念珠菌血清中的免疫球蛋白转移到DTH阳性小鼠中可增强保护作用，而对对照小鼠则不能保护其免受随后白色念珠菌的攻击。这些结果表明，在白色念珠菌感染小鼠的防御机制中，细胞介导免疫起主要作用，体液免疫起次要作用。
