Wiedermann Christian J, Noviello Chiara, Palmieri Claudia, Stefanizzi Pasquale, Piccoliori Giuliano, Engl Adolf, Tafuri Silvio
Institute of General Practice and Public Health, Claudiana Landesfachhochschule für Gesundheitsberufe, Bolzano, Italy
Department of Biomedical Science and Human Oncology, Universita degli Studi di Bari Aldo Moro, Bari, Italy.
BMJ Open. 2025 Jul 3;15(7):e095490. doi: 10.1136/bmjopen-2024-095490.
Vaccine hesitancy remains a critical public health challenge, especially in high-income countries. Gender differences in vaccine hesitancy can significantly affect vaccination rates and public health outcomes. The aim of this research is performing an umbrella review and meta-analysis to systematically investigate gender disparities in vaccine hesitancy for COVID-19 in high-income countries, as well as the quality, potential biases and dependability of epidemiological evidence.
The study will systematically search, extract and analyse data from reported systematic reviews and meta-analyses that focus specifically on gender differences in vaccine hesitancy. The search will include CINAHL, Cochrane Library, PubMed/MEDLINE, EMBASE and Epistemonikos for studies published from 2019 onward. The inclusion criteria will encompass systematic reviews and meta-analyses of non-interventional studies conducted in high-income countries. The identified factors contributing to vaccine hesitancy will be categorised based on demographic, psychological, social and economic dimensions. The methodological quality of the included meta-analyses will be assessed using the "Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews and Research Syntheses" tool.
Ethical approval is not required for this umbrella review. These results will be published in a peer-reviewed journal.
CRD42024572978.
疫苗犹豫仍然是一项严峻的公共卫生挑战，尤其是在高收入国家。疫苗犹豫方面的性别差异会显著影响疫苗接种率和公共卫生结果。本研究的目的是进行一项综合性回顾和荟萃分析，以系统调查高收入国家在新冠疫苗犹豫方面的性别差异，以及流行病学证据的质量、潜在偏倚和可靠性。
本研究将系统检索、提取和分析来自已发表的系统性综述和荟萃分析的数据，这些研究专门关注疫苗犹豫方面的性别差异。检索将包括CINAHL、Cochrane图书馆、PubMed/MEDLINE、EMBASE和Epistemonikos，以获取2019年以后发表的研究。纳入标准将涵盖在高收入国家进行的非干预性研究的系统性综述和荟萃分析。确定的导致疫苗犹豫的因素将根据人口统计学、心理、社会和经济维度进行分类。将使用“乔安娜·布里格斯研究所系统综述和研究综合批判性评价清单”工具评估纳入的荟萃分析的方法学质量。
本综合性回顾无需伦理批准。这些结果将发表在同行评审期刊上。
PROSPERO注册号：CRD42024572978。
