DeVoe I W, Gilka F, Gilchrist J E, Yu E
Infect Immun. 1977 Apr;16(1):271-9. doi: 10.1128/iai.16.1.271-279.1977.
The effects of a preparative dose of the leukocyte egesta containing degraded meningococci and a provocative dose of the meningococcal lipopolysaccharide on development of pathological lesions associated with disseminated intravascular coagulation were studied in tissues of 32 rabbits. These effects were compared with effects of a single dose of meningococcal lipopolysaccharide as well as leukocyte egesta containing degraded Staphylococcus epidermidis. Rabbits injected subcutaneously with egesta containing degraded meningococci followed after 12 h with meningococcal endotoxin (intravenously) exhibited heterophilic leukocytosis and disseminated intravascular coagulation mainly in the pulmonary capillaries and venules; focal necroses occurred in myocardium, lungs, and liver, whereas, cortical renal necrosis developed in lethal cases. Similar lesions, however, but less severe and with less frequency, developed even after a single dose of meningococcal endotoxin or after endotoxin that followed a dose of supernatant fluid from normal leukocytes. Our findings suggest that meningococcal material from polymorphonuclear degradation plays a role in the pathology characteristic of meningococcal septicemia.
在32只家兔的组织中，研究了含有降解脑膜炎球菌的白细胞排泄物预剂量以及脑膜炎球菌脂多糖激发剂量对与弥散性血管内凝血相关的病理损伤发展的影响。将这些影响与单剂量脑膜炎球菌脂多糖以及含有降解表皮葡萄球菌的白细胞排泄物的影响进行了比较。皮下注射含有降解脑膜炎球菌的排泄物，12小时后静脉注射脑膜炎球菌内毒素的家兔表现出嗜异性白细胞增多和弥散性血管内凝血，主要发生在肺毛细血管和小静脉；心肌、肺和肝出现局灶性坏死，而致死病例中出现肾皮质坏死。然而，即使在单剂量脑膜炎球菌内毒素或正常白细胞上清液剂量后注射内毒素后，也会出现类似的病变，但程度较轻且频率较低。我们的研究结果表明，多形核降解产生的脑膜炎球菌物质在脑膜炎球菌败血症的病理特征中起作用。
