Notsu K, Oka N, Note S, Nabeya N, Kuno S, Sakurami T
Diabetologia. 1985 Sep;28(9):660-2. doi: 10.1007/BF00291971.
Islet cell antibodies were studied in 1,112 non-diabetic adults, 473 normal school children and 162 Type 1 (insulin-dependent) diabetic patients in a Japanese population. The prevalence of islet cell antibodies was 0.5%, 0.4% and 32%, respectively. Most islet cell antibodies positive subjects with Type 1 diabetes had short duration of the disease. No patients who had over 10 years from the onset had islet cell antibodies. Six non-diabetic adults with islet cell antibodies were followed for 4 years. Only one with Hashimoto's thyroiditis showed a diabetic pattern in her oral glucose tolerance test. However, none developed overt insulin-dependent diabetes until 1984. Two out of these six subjects continued to be positive for both islet cell antibodies and antithyroid antibodies or antinuclear antibodies. Islet cell antibodies in the remaining four patients disappeared during the second year. It is difficult to predict the onset of Type 1 diabetes by islet cell antibodies in non-diabetic individuals because they may be transient.
在日本人群中，对1112名非糖尿病成年人、473名正常学童和162名1型（胰岛素依赖型）糖尿病患者进行了胰岛细胞抗体研究。胰岛细胞抗体的患病率分别为0.5%、0.4%和32%。大多数1型糖尿病胰岛细胞抗体阳性患者病程较短。发病超过10年的患者均无胰岛细胞抗体。对6名胰岛细胞抗体阳性的非糖尿病成年人进行了4年随访。只有1名患有桥本甲状腺炎的患者在口服葡萄糖耐量试验中呈现糖尿病模式。然而，直到1984年，无人发展为明显的胰岛素依赖型糖尿病。这6名受试者中有2名胰岛细胞抗体和抗甲状腺抗体或抗核抗体持续呈阳性。其余4名患者的胰岛细胞抗体在第二年消失。在非糖尿病个体中，很难通过胰岛细胞抗体预测1型糖尿病的发病，因为它们可能是短暂的。
