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2291名学童中胰岛细胞抗体、胰岛素抗体及高血糖的患病率

Prevalence of islet cell antibodies, insulin antibodies and hyperglycaemia in 2291 schoolchildren.

作者信息

Bergua M, Solé J, Marion G, Perez M C, Recasens A, Fernàndez J, Casamitjana R, Gomis R

机构信息

Centre Assistència Primaria, Institut Català de la Salut, Lleida, Spain.

出版信息

Diabetologia. 1987 Sep;30(9):724-6. doi: 10.1007/BF00296996.

DOI:10.1007/BF00296996
PMID:3322914
Abstract

Islet cell antibodies, insulin antibodies and hyperglycaemia were investigated in 2291 healthy schoolchildren. Eight of the subjects had islet cell antibodies and eight had insulin antibodies. However, no schoolchild who was positive for islet cell antibodies also had insulin antibodies present. Hyperglycaemia was observed in five children but neither islet cell antibodies nor insulin antibodies could be detected in the sera from these particular subjects.

摘要

对2291名健康学童进行了胰岛细胞抗体、胰岛素抗体和高血糖情况的调查。其中8名受试者有胰岛细胞抗体，8名有胰岛素抗体。然而，胰岛细胞抗体呈阳性的学童中没有同时存在胰岛素抗体的。5名儿童出现了高血糖，但在这些特定受试者的血清中未检测到胰岛细胞抗体和胰岛素抗体。

相似文献

1
Prevalence of islet cell antibodies, insulin antibodies and hyperglycaemia in 2291 schoolchildren.2291名学童中胰岛细胞抗体、胰岛素抗体及高血糖的患病率
Diabetologia. 1987 Sep;30(9):724-6. doi: 10.1007/BF00296996.
2
Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study.器官特异性自身免疫病患者的胰岛细胞抗体和胰岛素自身抗体。它们对1型（胰岛素依赖型）糖尿病发生发展的表现及预测价值。一项10年随访研究。
Diabetologia. 1987 May;30(5):292-7. doi: 10.1007/BF00299020.
3
[Islet-cell antibodies in juvenile diabetes mellitus (author's transl)].青少年糖尿病中的胰岛细胞抗体（作者译）
Dtsch Med Wochenschr. 1977 Aug 26;102(34):1221-4. doi: 10.1055/s-0028-1105483.
4
Relationship between serum insulin autoantibodies, islet cell antibodies and Coxsackie-B4 and mumps virus-specific antibodies at the clinical manifestation of type 1 (insulin-dependent) diabetes.1型（胰岛素依赖型）糖尿病临床表现时血清胰岛素自身抗体、胰岛细胞抗体与柯萨奇B4病毒及腮腺炎病毒特异性抗体之间的关系。
Diabetologia. 1988 Mar;31(3):146-52. doi: 10.1007/BF00276847.
5
Autoantibodies to pancreatic islet cells and insulin in IDDM families: the GAW5 data.胰岛素依赖型糖尿病家族中针对胰岛细胞和胰岛素的自身抗体：GAW5数据。
Genet Epidemiol. 1989;6(1):39-41. doi: 10.1002/gepi.1370060110.
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Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.患1型（胰岛素依赖型）糖尿病的风险及胰岛64K抗体的存在情况。
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Diabetologia. 1992 Nov;35(11):1068-73. doi: 10.1007/BF02221683.
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Population based study of prevalence of islet cell autoantibodies in monozygotic and dizygotic Danish twin pairs with insulin dependent diabetes mellitus.基于丹麦单卵和双卵双胞胎对胰岛素依赖型糖尿病患者胰岛细胞自身抗体患病率的研究。
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Detection of insulin antibodies in newly-diagnosed type 1 diabetic children after "acid-stripping" of sera.新诊断的1型糖尿病儿童血清“酸剥离”后胰岛素抗体的检测
Diabetes Res. 1987 Sep;6(1):1-4.
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Combined analysis of IDDM-related autoantibodies in healthy schoolchildren.健康学龄儿童中与胰岛素依赖型糖尿病相关自身抗体的联合分析。
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引用本文的文献

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Is It Time to Screen the General Population for Type 1 Diabetes?是时候对普通人群进行1型糖尿病筛查了吗？
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Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives.胰岛细胞抗体对美国学龄儿童胰岛素依赖型糖尿病的预测能力，与对未患病亲属的预测能力一样强。
J Clin Invest. 1994 Jun;93(6):2403-7. doi: 10.1172/JCI117247.
3
Combined analysis of islet cell antibodies which cross-react with mouse pancreas, antibodies to the M(r) 64,000 islet protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM.

本文引用的文献

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Diabetes in identical twins. A study of 200 pairs.同卵双胞胎中的糖尿病。一项对200对双胞胎的研究。
Diabetologia. 1981 Feb;20(2):87-93. doi: 10.1007/BF00262007.
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Decrease of antibodies to insulin, proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin.从常规牛肉胰岛素改为纯化猪胰岛素治疗后，胰岛素、胰岛素原及污染激素抗体水平降低。
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Clinical and subclinical organ-specific autoimmune manifestations in type 1 (insulin-dependent) diabetic patients and their first-degree relatives.
对有患胰岛素依赖型糖尿病风险的受试者体内与小鼠胰腺发生交叉反应的胰岛细胞抗体、针对分子量64,000的胰岛蛋白的抗体以及谷氨酸脱羧酶抗体进行联合分析。
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Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population.在儿童群体中，谷氨酸脱羧酶65抗体联合胰岛细胞胞浆抗体对预测胰岛素依赖型糖尿病的价值。
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Anti-islet cell and anti-insulin antibody production by CD5+ and CD5- B lymphocytes in IDDM.IDDM中CD5+和CD5- B淋巴细胞产生抗胰岛细胞和抗胰岛素抗体的情况。
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Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children.瑞典一年内所有患1型（胰岛素依赖型）糖尿病的儿童及配对的对照儿童体内的胰岛细胞抗体和其他器官特异性自身抗体。
Diabetologia. 1989 Jun;32(6):387-95. doi: 10.1007/BF00277264.
7
HLA antigens in Spanish type 1 diabetic population. Correlations with clinical, biological and autoimmune markers.西班牙1型糖尿病患者群体中的HLA抗原。与临床、生物学和自身免疫标志物的相关性。
Acta Diabetol Lat. 1990 Jul-Sep;27(3):215-22. doi: 10.1007/BF02581333.
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Influence of affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme linked immunosorbent assay. Demonstration using monoclonal antibodies raised against rDNA human proinsulin.
Diabetologia. 1991 Jul;34(7):463-8. doi: 10.1007/BF00403281.
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Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function--the Ulm-Frankfurt Population Study.
Klin Wochenschr. 1991 Oct 18;69(16):736-41. doi: 10.1007/BF01797611.
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An unusual case of recurrent hypoglycaemia: 10-year follow up of a child with insulin auto-immunity.
Eur J Pediatr. 1992 Jan;151(1):32-4. doi: 10.1007/BF02073886.
1型（胰岛素依赖型）糖尿病患者及其一级亲属的临床和亚临床器官特异性自身免疫表现。
Diabetologia. 1984 Jun;26(6):431-6. doi: 10.1007/BF00262215.
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Fluctuating islet-cell autoimmunity in unaffected relatives of patients with insulin-dependent diabetes.
Lancet. 1984 Apr 7;1(8380):764-6. doi: 10.1016/s0140-6736(84)91278-9.
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Islet cell antibodies in the Japanese population and subjects with type 1 (insulin-dependent) diabetes.日本人群及1型（胰岛素依赖型）糖尿病患者中的胰岛细胞抗体。
Diabetologia. 1985 Sep;28(9):660-2. doi: 10.1007/BF00291971.
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Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?胰岛素自身抗体是胰岛素依赖型糖尿病的标志物吗？
Diabetes. 1986 Aug;35(8):894-8. doi: 10.2337/diab.35.8.894.
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Anti-insulin antibodies in children with type I diabetes mellitus. Genetic regulation of production and presence at diagnosis before insulin replacement.1型糖尿病患儿中的抗胰岛素抗体。胰岛素替代治疗前诊断时抗体产生的遗传调控及抗体的存在情况。
Diabetes. 1986 Jun;35(6):634-41. doi: 10.2337/diab.35.6.634.
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Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus.对胰岛素的自身免疫、β细胞功能障碍与胰岛素依赖型糖尿病的发展
Diabetes. 1986 Feb;35(2):139-42. doi: 10.2337/diab.35.2.139.
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Value of insulin autoantibodies as serum markers for insulin-dependent diabetes mellitus.胰岛素自身抗体作为胰岛素依赖型糖尿病血清标志物的价值。
Lancet. 1985 Mar 2;1(8427):480-1. doi: 10.1016/s0140-6736(85)92086-0.