White D P, Schneider B K, Santen R J, McDermott M, Pickett C K, Zwillich C W, Weil J V
J Appl Physiol (1985). 1985 Nov;59(5):1452-7. doi: 10.1152/jappl.1985.59.5.1452.
There is increasing evidence that men have higher ventilatory responses to chemical stimuli than age-matched women and that certain disorders of respiratory rhythmicity, particularly sleep apnea, occur more commonly in men. Accordingly, we studied the influence of the male hormone, testosterone, on the control of breathing. Twelve hypogonadal males were studied at least 30 (mean +/- SE: 69.7 +/- 8.9) days after discontinuing testosterone replacement and again following hormone administration. In each subject plasma testosterone concentration, metabolic rate [O2 consumption (VO2) and CO2 production (VCO2)], minute ventilation (VE), and chemosensitivity [hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses] were determined on and off hormone replacement. With testosterone administration VO2 increased from 248 +/- 15 to 276 +/- 18 ml/min (P less than 0.05), with VCO2 showing a similar but nonsignificant trend. This was associated with an increase in VE from 8.41 +/- 0.78 to 9.91 +/- 0.75 l/min (P less than 0.05) but no change in PCO2. The HVR, expressed as A, increased 44% with hormone replacement from a value of 122 +/- 23 to 176 +/- 28 (P less than 0.01), whereas the HCVR was minimally affected by testosterone administration. These findings may in part explain the previously described differences between male and female subjects in hypoxic sensitivity.
越来越多的证据表明，男性对化学刺激的通气反应比年龄匹配的女性更高，并且某些呼吸节律紊乱，尤其是睡眠呼吸暂停，在男性中更为常见。因此，我们研究了雄性激素睾酮对呼吸控制的影响。对12名性腺功能减退的男性在停止睾酮替代治疗至少30天（平均±标准误：69.7±8.9）后以及再次给予激素后进行了研究。在每个受试者身上，测定了激素替代治疗前后的血浆睾酮浓度、代谢率[耗氧量（VO2）和二氧化碳产生量（VCO2）]、分钟通气量（VE）以及化学敏感性[低氧（HVR）和高碳酸血症（HCVR）通气反应]。给予睾酮后，VO2从248±15增加到276±18 ml/min（P<0.05），VCO2呈现类似但无统计学意义的趋势。这与VE从8.41±0.78增加到9.91±0.75 l/min（P<0.05）相关，但PCO2无变化。以A表示的HVR在激素替代治疗后增加了44%，从122±23增加到176±28（P<0.01），而HCVR受睾酮给药的影响最小。这些发现可能部分解释了先前描述的男性和女性受试者在低氧敏感性方面的差异。
