Jiang Yuanyuan, Wu Xiangyi, Wang Xiaoju, Kong Bin, Wang Jinglin, Zhang Hongbo
Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.
Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, Finland.
Mater Today Bio. 2025 Jun 24;33:102002. doi: 10.1016/j.mtbio.2025.102002. eCollection 2025 Aug.
Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material with antibacterial properties. Benefiting from these combined features, the bioinspired living hydrogel significantly promoted wound repair in evaluations. Collectively, these findings highlight the potential of our bioinspired living hydrogel as a promising therapeutic strategy for enhanced wound healing.
血液在伤口愈合中起着至关重要的作用，因为血小板（PLT）启动初级止血，而红细胞（RBC）持续供应氧气。受红细胞和血小板内在功能的启发，我们开发了一种包含红细胞、血小板和黑磷量子点（BP QD）的活性水凝胶，以加速伤口愈合。由于其三维（3D）褶皱表面结构和优异的生物相容性，该水凝胶表现出更高的细胞接种效率，并为止血和组织再生提供了有效的支持。通过利用BP QD的光响应特性，水凝胶获得了可控的光热效应，实现了近红外触发的氧气释放。此外，将多粘菌素掺入水凝胶基质中，使该材料具有抗菌性能。受益于这些综合特性，这种受生物启发的活性水凝胶在评估中显著促进了伤口修复。总的来说，这些发现突出了我们受生物启发的活性水凝胶作为一种有前途的治疗策略以增强伤口愈合的潜力。
