Gill G V, Baylis P H, Flear C T, Lawson J Y
J R Soc Med. 1985 Dec;78(12):1009-13. doi: 10.1177/014107688507801206.
In experiments on 8 healthy young male volunteers, the ingestion of a large meal was found to cause plasma osmolality to rise from 288.8 +/- 0.8 (mean +/- s.e. mean) to 295.6 +/- 0.9 mmol/kg at 4 hours (P less than 0.001). There was an accompanying rise in plasma sodium (Na) from 141.9 +/- 0.8 to 144.6 +/- 0.8 mmol/l, also at 4 hours (P less than 0.01), but little change in other plasma electrolytes. Serum total amino acids rose slightly, non-esterified fatty acid fell minimally and changes in blood glucose concentrations were unremarkable. Thirst was experienced at plasma osmolality of 294.8 +/- 0.7 mmol/kg. Repeating the experiment either without food, or with the salt content of the meal only, was without effect on plasma Na, other solutes or osmolality. Postprandial hypersomolality and hypernatraemia is probably due to movement of water from the vascular compartment to the gut, or into cells. Plasma osmolality is best measured in the fasting state.
在对8名健康年轻男性志愿者进行的实验中，发现摄入一顿大餐会使血浆渗透压在4小时内从288.8±0.8（均值±标准误均值）升至295.6±0.9 mmol/kg（P<0.001）。同样在4小时时，血浆钠（Na）从141.9±0.8升至144.6±0.8 mmol/L（P<0.01），但其他血浆电解质变化不大。血清总氨基酸略有上升，非酯化脂肪酸略有下降，血糖浓度变化不明显。当血浆渗透压达到294.8±0.7 mmol/kg时会感到口渴。在不进食或仅摄入餐食中盐分的情况下重复该实验，对血浆钠、其他溶质或渗透压均无影响。餐后高渗血症和高钠血症可能是由于水从血管腔转移至肠道或进入细胞所致。血浆渗透压最好在空腹状态下测量。
