Sukanjanapong Siriorn, Ploydaeng Monthanat, Wattanakrai Penpun
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clin Cosmet Investig Dermatol. 2024 Nov 1;17:2427-2436. doi: 10.2147/CCID.S476004. eCollection 2024.
Data of objective skin barrier parameters in acne patients with and without therapy compared with normal controls are limited. This information could provide more insight into the pathogenesis of acne vulgaris and optimal acne treatment.
To measure and compare skin barrier parameters in a large cohort of acne patients with and without therapy compared with normal controls.
This cross-sectional analytic study was conducted on healthy Thai volunteers. After completing a questionnaire on their general information and skincare routine, volunteers received a full skin examination and were divided into subjects with and without acne. Skin barrier parameters, including the transepidermal water loss (TEWL), skin hydration and sebum production were measured and compared between the two groups. Factors that may affect each parameter were analysed and adjusted for in a multivariate regression analysis. In addition, data from acne patients with and without treatment were evaluated.
The study included 316 volunteers (164 acne patients, 152 controls), mostly female (79% acne, 78% controls). The mean age of the acne group was considerably lower than that of the control group (34 vs 48.6 years (p < 0.001)). Acne patients showed significantly higher TEWL (13.16 vs 10.63 g/m²/day, p < 0.001), sebum production (median 3 vs 0 A.U, p = 0.002), and skin hydration (244.60 vs 222.60 uS, p = 0.001). These differences remained significant after adjusting for confounding factors. Additionally, significant differences were observed between controls, acne. Patients receiving and not receiving acne medications. The highest TEWL was observed in acne patients receiving treatment, followed by untreated acne patients and normal controls (p = 0.0003). Skin hydration exhibited a comparable pattern (p = 0.03).
There were significantly higher TEWL, sebum production and hydration in acne patients. Acne treatment further impaired the skin barrier. These findings support the possible benefits of moisturisers with barrier-enhancing properties in patients receiving acne medications.
与正常对照组相比，关于接受治疗和未接受治疗的痤疮患者客观皮肤屏障参数的数据有限。这些信息可以为寻常痤疮的发病机制和最佳痤疮治疗提供更多见解。
测量并比较一大群接受治疗和未接受治疗的痤疮患者与正常对照组的皮肤屏障参数。
本横断面分析研究针对健康的泰国志愿者进行。在完成关于他们的一般信息和护肤习惯的问卷调查后，志愿者接受全面的皮肤检查，并被分为有痤疮和无痤疮的受试者。测量并比较两组之间的皮肤屏障参数，包括经表皮水分流失（TEWL）、皮肤水合作用和皮脂分泌。分析可能影响每个参数的因素，并在多变量回归分析中进行调整。此外，评估了接受治疗和未接受治疗的痤疮患者的数据。
该研究包括316名志愿者（164名痤疮患者，152名对照组），大多数为女性（痤疮组79%，对照组78%）。痤疮组的平均年龄明显低于对照组（34岁对48.6岁，p<0.001）。痤疮患者的TEWL显著更高（13.16对10.63g/m²/天，p<0.001），皮脂分泌（中位数3对0任意单位，p=0.002），以及皮肤水合作用（244.60对222.60微西门子，p=0.001）。在调整混杂因素后，这些差异仍然显著。此外，在对照组、痤疮患者、接受和未接受痤疮药物治疗的患者之间观察到显著差异。接受治疗痤疮患者的TEWL最高，其次是未治疗的痤疮患者和正常对照组（p=0.0003）。皮肤水合作用呈现类似模式（p=0.03）。
痤疮患者的TEWL、皮脂分泌和水合作用显著更高。痤疮治疗进一步损害皮肤屏障。这些发现支持在接受痤疮药物治疗的患者中使用具有增强屏障特性的保湿剂可能带来的益处。
