Mapping the research trends and hotspots on solid pulmonary nodules from 2000-2024: insights from bibliometric analysis.

BACKGROUND

Due to extensive low-dose computed tomography (CT) screening, the detection rate of solid pulmonary nodules (PNs) is constantly rising. However, existing studies lack a comprehensive understanding of its emerging research trends and interdisciplinary progress, especially in terms of artificial intelligence (AI) integration and molecular characteristics. In this study, we conduct a comprehensive bibliometric analysis to clarify the current research trends and predict future research hotspots in this field, in order to improve diagnostic accuracy, reduce overtreatment, and promote innovation in precise chest oncology.

METHODS

Relevant publications regarding solid PNs were acquired from the Web of Science Core Collection (WoSCC) database [2000-2024]. Scientific landscape of solid PNs was illustrated by quantitatively assessing the scientific output and impact of various academic subjects (i.e., authors, institutions, journal, countries/regions) and qualitatively generating collaboration networks using CiteSpace and Bibliometrix. Lastly, burst detection, clustering analysis and thematic map analysis were implemented to depict shifts in the research frontier of solid PNs.

RESULTS

Since 2000, a total of 1,413 original articles on pulmonary solid nodules (SNs) have been published. The United States was the leading country in terms of publication volume and centrality in this field. Prof. Kurzrock Razelle from the Medical College of Wisconsin, USA, had the most publications and the highest scientific impact in the field. Clinical Cancer Research published the most manuscripts and had the highest impact in the field. Research institutions from the United States were predominant in the field and several institutions from China were found to have strong influence in the recent years. Current key research foci of solid PNs included tumor size, diagnosis, classification, malignancy, radiomics, segmentectomy, the Response Evaluation Criteria in Solid Tumors (RECIST). Moreover, molecular profile analysis, brain metastases (BMs), lymph node (LN) metastasis, solid lipid nanoparticles (SLNs) and immunotherapy are the emerging research topics.

CONCLUSIONS

The in-depth bibliometric analysis outlines the research landscape in the field of solid PNs, identifying current research trends and hot topics that can guide future research directions. AI-based prediction, diagnosis, and minimally invasive treatment are potential avenues for managing solid PNs.