Lennerz Jochen K, Farfsing Alexandra, Kiehl Tim-Rasmus, Perner Sven, van Duuren Joost, Christ Marleen, Farfsing Jan W
Boston Gene, Waltham, MA, USA.
Roche Diagnostics Deutschland GmbH, Mannheim, Germany.
J Pathol Inform. 2025 Jul 3;18:100460. doi: 10.1016/j.jpi.2025.100460. eCollection 2025 Aug.
Digital innovation in precision diagnostics requires addressing complex challenges, such as implementation, adoption, equity, and sustainability. This study introduces a co-creation framework that leverages the pre-competitive space to drive collaborative innovation in personalized diagnostics. Over 5 years, a multidisciplinary community of stakeholders from computational pathology, oncology, genetics, digital medicine, and industry engaged in design-thinking workshops to identify unmet medical needs and co-develop solutions. These efforts led to 15 pilot projects, with 7 successfully implemented, including an automated lab system enhancing workflow efficiency. The co-creation approach fostered strategic alignment, community building, and integration of diverse perspectives, resulting in tangible outputs (datasets, publications, and resources) and intangible benefits (networking, market insight). This framework demonstrates how collaborative ecosystems accelerate diagnostic innovations and offer a scalable model for advancing personalized healthcare. Co-creation addresses interdisciplinary silos, promotes patient-centered solutions, and adapts to evolving regulatory landscapes, making it a catalyst for impactful healthcare transformation.
精准诊断中的数字创新需要应对复杂的挑战，如实施、采用、公平性和可持续性。本研究引入了一个共同创造框架，该框架利用竞争前空间来推动个性化诊断中的合作创新。在5年多的时间里，来自计算病理学、肿瘤学、遗传学、数字医学和行业的多学科利益相关者群体参与了设计思维研讨会，以确定未满足的医疗需求并共同开发解决方案。这些努力促成了15个试点项目，其中7个成功实施，包括一个提高工作流程效率的自动化实验室系统。共同创造方法促进了战略协调、社区建设以及不同观点的整合，产生了切实的成果（数据集、出版物和资源）和无形的收益（网络、市场洞察力）。该框架展示了协作生态系统如何加速诊断创新，并为推进个性化医疗提供了一个可扩展的模式。共同创造消除了跨学科的壁垒，促进了以患者为中心的解决方案，并适应不断变化的监管环境，使其成为有影响力的医疗变革的催化剂。
