Ramschütz Constanze, Kloth Christopher, Vogele Daniel, Baum Thomas, Rühling Sebastian, Beer Meinrad, Jansen Jan U, Schlager Benedikt, Wilke Hans-Joachim, Kirschke Jan S, Sollmann Nico
Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany.
Eur Spine J. 2025 Jul 21. doi: 10.1007/s00586-025-09146-8.
To investigate lumbar vertebral volumetric bone mineral density (vBMD) from ex vivo opportunistic multi-detector computed tomography (MDCT) scans using different protocols, and compare it to dedicated quantitative CT (QCT) values from the same specimens.
Cadavers from two female donors (ages 62 and 68 years) were scanned (L1-L5) using six different MDCT protocols and one dedicated QCT scan. Opportunistic vBMD was extracted using an artificial intelligence-based algorithm. The vBMD measurements from the six MDCT protocols, which varied in peak tube voltage (80-140 kVp), tube load (72-200 mAs), slice thickness (0.75-1 mm), and/or slice increment (0.5-0.75 mm), were compared to those obtained from dedicated QCT.
A strong positive correlation was observed between vBMD from opportunistic MDCT and reference QCT (ρ = 0.869, p < 0.01). Agreement between vBMD measurements from MDCT protocols and the QCT reference standard according to the intraclass correlation coefficient (ICC) was 0.992 (95% confidence interval [CI]: 0.982-0.998). Bland-Altman analysis showed biases ranging from - 12.66 to 8.00 mg/cm³ across the six MDCT protocols, with all data points falling within the respective limits of agreement (LOA) for both cadavers.
Opportunistic vBMD measurements of lumbar vertebrae demonstrated reliable consistency ex vivo across various scan parameters when compared to dedicated QCT.
利用不同方案对离体机会性多排螺旋计算机断层扫描（MDCT）进行腰椎椎体体积骨密度（vBMD）研究，并将其与同一标本的专用定量CT（QCT）值进行比较。
对两名女性捐赠者（年龄分别为62岁和68岁）的尸体进行扫描（L1-L5），采用六种不同的MDCT方案和一次专用QCT扫描。利用基于人工智能的算法提取机会性vBMD。将六种MDCT方案的vBMD测量值与专用QCT获得的测量值进行比较，这六种方案在管电压峰值（80-140 kVp）、管负荷（72-200 mAs）、层厚（0.75-1 mm）和/或层间距（0.5-0.75 mm）方面有所不同。
机会性MDCT的vBMD与参考QCT之间存在强正相关（ρ = 0.869，p < 0.01）。根据组内相关系数（ICC），MDCT方案的vBMD测量值与QCT参考标准之间的一致性为0.992（95%置信区间[CI]：0.982-0.998）。Bland-Altman分析显示，六种MDCT方案的偏差范围为-12.66至8.00 mg/cm³，所有数据点均落在两具尸体各自的一致性界限（LOA）内。
与专用QCT相比，腰椎椎体的机会性vBMD测量在离体状态下，跨各种扫描参数显示出可靠的一致性。
