Lazebnik N, Noy S, Lazebnik R, Hezroni Y, Amoday I, Aviram A
Postgrad Med J. 1985 Nov;61(721):979-81. doi: 10.1136/pgmj.61.721.979.
The serum half-life of gentamicin following an intravenous dose was compared between 19 pregnant women (28-34 weeks of pregnancy) with premature rupture of the membranes and 17 non-pregnant women with pelvic inflammatory disease, the groups being age and weight matched. A significant reduction of gentamicin half-life was found in the pregnant group.
对19名胎膜早破的孕妇(妊娠28 - 34周)和17名患有盆腔炎的非孕妇进行了比较,两组在年龄和体重上相匹配,比较了静脉注射庆大霉素后的血清半衰期。结果发现,孕妇组庆大霉素半衰期显著缩短。