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庆大霉素血清半衰期:孕妇与非孕妇的比较

Gentamicin serum half-life: a comparison between pregnant and non-pregnant women.

作者信息

Lazebnik N, Noy S, Lazebnik R, Hezroni Y, Amoday I, Aviram A

出版信息

Postgrad Med J. 1985 Nov;61(721):979-81. doi: 10.1136/pgmj.61.721.979.

DOI:10.1136/pgmj.61.721.979
PMID:4070116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2418464/
Abstract

The serum half-life of gentamicin following an intravenous dose was compared between 19 pregnant women (28-34 weeks of pregnancy) with premature rupture of the membranes and 17 non-pregnant women with pelvic inflammatory disease, the groups being age and weight matched. A significant reduction of gentamicin half-life was found in the pregnant group.

摘要

对19名胎膜早破的孕妇(妊娠28 - 34周)和17名患有盆腔炎的非孕妇进行了比较,两组在年龄和体重上相匹配,比较了静脉注射庆大霉素后的血清半衰期。结果发现,孕妇组庆大霉素半衰期显著缩短。

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本文引用的文献

1
Antibiotic use during pregnancy and the postpartum period.孕期及产后抗生素的使用。
Clin Obstet Gynecol. 1983 Jun;26(2):391-406. doi: 10.1097/00003081-198306000-00021.
2
Correlation of serum creatinine concentration and gentamicin half-life.血清肌酐浓度与庆大霉素半衰期的相关性。
JAMA. 1972 Feb 21;219(8):1037-41.
3
Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration.肾功能不全患者的庆大霉素剂量。根据内生肌酐清除率和血清肌酐浓度进行调整。
Ann Intern Med. 1971 Feb;74(2):192-7. doi: 10.7326/0003-4819-74-2-192.