Zara Sabeen, Koleri Junais, Ali Maisa, Abid Fatma, Parengal Jabeed, Hamed Manal Mahmoud, Maslamani Muna Al
Division of Infectious Diseases, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
College of Medicine, Qatar University, Qatar.
IDCases. 2025 Jul 9;41:e02316. doi: 10.1016/j.idcr.2025.e02316. eCollection 2025.
Splenic abscess is a rare, life-threatening condition often resulting from hematogenous spread or contiguous infection. We report a 14-year-old immunocompetent male presenting with fever, diarrhea, and left upper quadrant pain. A CT scan revealed a 14-cm splenic abscess. Initial blood and aspirate cultures were negative, and empirical ceftriaxone and metronidazole yielded poor response. Multiplex PCR Gastrointestinal Panel and 16S rRNA sequencing identified prompting targeted therapy with azithromycin and meropenem. Percutaneous drainage and antibiotics led to resolution. This case underscores the role of molecular diagnostics in culture-negative infections and highlights as a rare cause of splenic abscess in immunocompetent patients.
脾脓肿是一种罕见的、危及生命的疾病，通常由血行播散或邻近感染引起。我们报告一例14岁免疫功能正常的男性，表现为发热、腹泻和左上腹疼痛。CT扫描显示一个14厘米的脾脓肿。最初的血液和抽吸物培养均为阴性，经验性使用头孢曲松和甲硝唑效果不佳。多重PCR胃肠道检测板和16S rRNA测序确定了病因，从而促使使用阿奇霉素和美罗培南进行靶向治疗。经皮引流和抗生素治疗使病情得到缓解。该病例强调了分子诊断在培养阴性感染中的作用，并突出了[此处原文缺失相关内容]作为免疫功能正常患者脾脓肿的罕见病因。
