Future Frontiers in Bioinspired Implanted Biomaterials.

Bioinspired materials draw design inspiration from nature's principles and integrate them with engineering requirements to construct highly functional and complex systems across multiple length scales. Bioinspired implanted biomaterials are highly promising in regenerative medicine, being designed to integrate customized materials with biological functions to replicate the complexity of living tissues. Organs are dynamic, multi-interface architectures with intricate mechanical, biochemical, and physiological properties, posing a major challenge for accurate replication. This perspective explores recent advancements in the design of natural and synthetic biomaterials, focusing on strategies like cell-laden scaffolds and cell-free constructs, which interact dynamically with the body's microenvironments to promote tissue regeneration. How smart biomaterials that respond to biological stimuli are reshaping material functionalization, offering long-term therapeutic solutions is examined. Additionally, how innovations in 3D printing, nanotechnology, and personalized medicine are overcoming current barriers and improving clinical use. Overcoming the challenges associated with replicating complex tissue structures, along with technological advancements, will be crucial to unlocking the full clinical potential of bioinspired implanted biomaterials.