Gu Qi, Yuan Rui, Sun Dadi, Wallace Gordon
Human Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, P. R. China.
Beijing Institute for Stem Cell and Regenerative Medicine, Chaoyang District, Beijing, 100101, P. R. China.
Adv Mater. 2025 Sep;37(36):e06323. doi: 10.1002/adma.202506323. Epub 2025 Jul 30.
Bioinspired materials draw design inspiration from nature's principles and integrate them with engineering requirements to construct highly functional and complex systems across multiple length scales. Bioinspired implanted biomaterials are highly promising in regenerative medicine, being designed to integrate customized materials with biological functions to replicate the complexity of living tissues. Organs are dynamic, multi-interface architectures with intricate mechanical, biochemical, and physiological properties, posing a major challenge for accurate replication. This perspective explores recent advancements in the design of natural and synthetic biomaterials, focusing on strategies like cell-laden scaffolds and cell-free constructs, which interact dynamically with the body's microenvironments to promote tissue regeneration. How smart biomaterials that respond to biological stimuli are reshaping material functionalization, offering long-term therapeutic solutions is examined. Additionally, how innovations in 3D printing, nanotechnology, and personalized medicine are overcoming current barriers and improving clinical use. Overcoming the challenges associated with replicating complex tissue structures, along with technological advancements, will be crucial to unlocking the full clinical potential of bioinspired implanted biomaterials.
受生物启发的材料从自然原理中汲取设计灵感，并将其与工程要求相结合，以构建跨越多个长度尺度的高功能和复杂系统。受生物启发的植入式生物材料在再生医学中极具前景，旨在将定制材料与生物功能相结合，以复制活组织的复杂性。器官是具有复杂机械、生化和生理特性的动态多界面结构，这对精确复制构成了重大挑战。本文探讨了天然和合成生物材料设计的最新进展，重点关注载细胞支架和无细胞构建体等策略，这些策略与身体的微环境动态相互作用以促进组织再生。研究了响应生物刺激的智能生物材料如何重塑材料功能化，提供长期治疗解决方案。此外，3D打印、纳米技术和个性化医学的创新如何克服当前障碍并改善临床应用。克服与复制复杂组织结构相关的挑战以及技术进步，对于释放受生物启发的植入式生物材料的全部临床潜力至关重要。
