von Wendt L, Rantakallio P
Childs Nerv Syst. 1986;2(2):80-2. doi: 10.1007/BF00286225.
A 1-year birth cohort from northern Finland comprised 12,058 children, 96% of all live-born infants born in the region in 1966. The development and morbidity of these children were followed up to the age of 14 years. Altogether, 40 children (25 boys and 15 girls) 3.32 per 1,000 suffered from congenital malformations of the central nervous system (CNS). Fourteen (1.16) had spina bifida cystica, 17 (1.41) hydrocephalus, and 9 (0.75) miscellaneous other malformations. Altogether, 14 children died during the follow-up period, giving a prevalence of 2.21 per 1,000 at 14 years. Additional neurological handicaps, mental retardation, cerebral palsy or epilepsy were present in 23 children, 13 of whom had multiple handicaps. Of these children 26% were able to attend an ordinary school in the class appropriate for their age. It is concluded that the incidences for CNS malformations obtained in this study are very much higher than those reported in the Finnish Register of Congenital Malformations, but correspond very well to the figures obtained in the British 1958 birth cohort, which was studied in an analogous way.
来自芬兰北部的一个1年出生队列包含12,058名儿童，占该地区1966年所有活产婴儿的96%。对这些儿童的发育和发病率进行了随访，直至14岁。共有40名儿童（25名男孩和15名女孩），每1000人中有3.32人患有中枢神经系统（CNS）先天性畸形。14人（1.16）患有脊柱裂囊肿，17人（1.41）患有脑积水，9人（0.75）患有其他各类畸形。在随访期间共有14名儿童死亡，14岁时的患病率为每1000人中有2.21人。另有23名儿童存在神经功能障碍、智力迟钝、脑瘫或癫痫，其中13人有多种障碍。这些儿童中有26%能够在适合其年龄的班级就读普通学校。研究得出结论，本研究中获得的中枢神经系统畸形发病率远高于芬兰先天性畸形登记处报告的发病率，但与以类似方式研究的英国1958年出生队列所获得的数据非常吻合。
