酮康唑与其他固醇合成抑制剂联合使用对真菌生长的影响。
Effect of ketoconazole in combination with other inhibitors of sterol synthesis on fungal growth.
作者信息
Sud I J, Feingold D S
出版信息
Antimicrob Agents Chemother. 1985 Oct;28(4):532-4. doi: 10.1128/AAC.28.4.532.
Abstract
The effect of combination of ketoconazole with other sterol synthesis inhibitors on fungal growth was tested against a variety of fungi selected for resistance to ketoconazole. All of the sterol inhibitors, at concentrations lower than their MICs, caused an increase greater than fourfold in the ketoconazole susceptibility of some fungi. Some of the sterol synthesis inhibitors showed this effect with ketoconazole at levels that may be achieved clinically.
摘要
酮康唑与其他甾醇合成抑制剂联合使用对真菌生长的影响，是针对多种对酮康唑耐药的真菌进行测试的。所有甾醇抑制剂在低于其最低抑菌浓度（MIC）的浓度下，都会使某些真菌对酮康唑的敏感性提高四倍以上。一些甾醇合成抑制剂与酮康唑联合使用时，在临床可能达到的水平下就显示出了这种效果。
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