Motazedian Pouya, Prosperi-Porta Graeme, Mathieu Marie-Eve, Beauregard Nickolas, Knoll William, Quinn Nicholas, Parlow Simon, Di Santo Pietro, Abdel-Razek Omar, Jung Richard, Kolobaric Nikola, Barbour William, Nelson David, Simard Trevor, Jentzer Jacob C, Mathew Rebecca, Wells George A, Ramirez F Daniel, Hibbert Benjamin
CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
BMC Cardiovasc Disord. 2025 Jul 30;25(1):556. doi: 10.1186/s12872-025-05024-9.
Electrical storm (ES) is associated with a significant risk of morbidity and mortality. Despite this, there has been limited research in ES resulting in uncertainty and inconsistency in the management of this life-threatening condition. The objective of this scoping review was to define the current body of literature evaluating pharmacologic and non-pharmacologic therapies used in the management of ES. A comprehensive search of Medline, CENTRAL and Embase was completed on January 11, 2025. Primary studies on pharmacotherapies in ES were included if they reported therapy-related outcomes and included ≥ 5 adult patients. A total of 45 studies met the inclusion criteria. Four studies were randomized control trials (three trials had overlapping cohorts) and the remaining were observational studies. Amiodarone, quinidine, landiolol, isoproterenol, and mexiletine were the most studied medications. The use of sedation for ES was exclusively studied in the context of mechanical ventilation. There was an increase in the number of ES studies over time, but sample sizes remained small and unchanged. Existing evidence to guide the management of ES is predominantly based on small observational studies. High quality data to inform the management of ES is needed.
电风暴（ES）与显著的发病和死亡风险相关。尽管如此，关于ES的研究有限，导致在管理这种危及生命的病症时存在不确定性和不一致性。本范围综述的目的是界定当前评估用于管理ES的药物和非药物疗法的文献。于2025年1月11日完成了对Medline、CENTRAL和Embase的全面检索。如果关于ES药物治疗的主要研究报告了与治疗相关的结果且纳入了≥5名成年患者，则将其纳入。共有45项研究符合纳入标准。4项研究为随机对照试验（3项试验有重叠队列），其余为观察性研究。胺碘酮、奎尼丁、兰地洛尔、异丙肾上腺素和美西律是研究最多的药物。仅在机械通气背景下研究了ES的镇静使用情况。随着时间的推移，ES研究数量有所增加，但样本量仍然较小且没有变化。指导ES管理的现有证据主要基于小型观察性研究。需要高质量数据来为ES的管理提供信息。
