Michelotti Angela, Cestone Enza, De Ponti Ileana, Pisati Marta, Sparta Eleonora, Tursi Francesco
In Vivo Laboratory, San Martino Siccomario (Pv), Complife Italia Srl, Italy.
Laboratory Management, Garbagnate Milanese (Mi), Complife Italia Srl, Italy.
Eur J Dermatol. 2021 Dec 1;31(6):798-805. doi: 10.1684/ejd.2021.4176.
Skin aging is a physiological condition which leads to structural and functional changes in skin. Common signs of aging are the gradual decrease of hyaluronic acid (HA) in the skin and the appearance of wrinkles. Therefore, effective HA supplementation could counteract HA deficiency and improve skin parameters, providing a safe profile for use which is easily incorporated into daily routine.
To evaluate a food supplement containing a wide range of hyaluronans of different molecular weights (full-spectrum hyaluronan [FS-HA]) in order to ameliorate skin conditions in adult females.
MATERIALS & METHODS: Sixty subjects showing mild-to-moderate skin aging signs were enrolled in a double-blind, randomized, placebo-controlled clinical trial to receive 200 mg/day of FS-HA (ExceptionHYAL® Star), or placebo, for 28 days. Dermatological parameters were evaluated at T and T. Product efficacy and tolerance were further evaluated using a self-assessment questionnaire. In addition, HA serum levels were weekly evaluated in a proportion of enrolled subjects.
After only 28 days, subjects in the active arm showed a statistically significant improvement in all evaluated dermatological parameters related to skin aging. Skin became more hydrated (+10.6%) and protected from dehydration, with a decrease in both wrinkle depth (-18.8%) and volume (-17.6%) and increase in elasticity and firmness (+5.1%). Instrumental results were further confirmed by self-assessment questionnaire outcomes.
Administration of a food supplement based on innovative hyaluronans from bio-fermentation, characterized by a wide range of molecular weights, resulted in a quick and significant amelioration of typical signs of skin aging.
皮肤老化是一种导致皮肤结构和功能发生变化的生理状况。老化的常见迹象是皮肤中透明质酸（HA）逐渐减少以及皱纹出现。因此，有效的HA补充可以抵消HA缺乏并改善皮肤参数，提供易于融入日常生活的安全使用特性。
评估一种含有多种不同分子量透明质酸（全谱透明质酸[FS-HA]）的食品补充剂，以改善成年女性的皮肤状况。
60名有轻度至中度皮肤老化迹象的受试者参加了一项双盲、随机、安慰剂对照临床试验，接受200毫克/天的FS-HA（ExceptionHYAL® Star）或安慰剂，为期28天。在T0和T28时评估皮肤学参数。使用自我评估问卷进一步评估产品疗效和耐受性。此外，对一部分入组受试者每周评估HA血清水平。
仅28天后，活性组受试者在所有评估的与皮肤老化相关的皮肤学参数方面均有统计学显著改善。皮肤变得更水润（+10.6%），得到更好的保湿保护，皱纹深度（-18.8%）和体积（-17.6%）均减少，弹性和紧致度增加（+5.1%）。仪器测量结果得到自我评估问卷结果的进一步证实。
给予一种基于生物发酵的具有多种分子量的创新透明质酸的食品补充剂，可快速且显著改善皮肤老化的典型迹象。
