Chick W L, Perna J J, Lauris V, Low D, Galletti P M, Panol G, Whittemore A D, Like A A, Colton C K, Lysaght M J
Science. 1977 Aug 19;197(4305):780-2. doi: 10.1126/science.407649.
An artificial pancreas consisting of beta cells cultured on synthetic semipermeable hollow fibers was tested in rats with alloxan-induced diabetes. When implanted ex vivo as arteriovenous shunts in the circulatory system these devices lowered concentrations of plasma glucose from 533 to between 110 and 130 milligrams per 100 milliliters, increased concentrations of plasma insulin, and restored intravenous glucose tolerance tests essentially to normal.
一种由在合成半透性中空纤维上培养的β细胞组成的人工胰腺在患有四氧嘧啶诱导糖尿病的大鼠身上进行了测试。当作为动静脉分流器离体植入循环系统时，这些装置将血浆葡萄糖浓度从每100毫升533毫克降至110至130毫克之间，提高了血浆胰岛素浓度，并使静脉葡萄糖耐量试验基本恢复正常。
