Chahal P, Inglesby D V, Sleightholm M, Kohner E M
Hypertension. 1985 Nov-Dec;7(6 Pt 2):II79-83. doi: 10.1161/01.hyp.7.6_pt_2.ii79.
A retrospective 5-year study examined the relationship between blood pressure and the severity and progression of mild background retinopathy in 48 patients with non-insulin-dependent diabetes and 38 with insulin-dependent diabetes who did not receive treatment in either eye for at least 3 years from their initial visit. All patients had annual medical and ophthalmic examinations including fundus photography. Retinopathy was assessed from fundus photographs using the Hammersmith grading system. Initial mean systolic and diastolic blood pressures (mm Hg) were significantly higher in those with non-insulin-dependent diabetes (149/88) than in patients with insulin-dependent diabetes (129/81). The former had significantly worse retinopathy than the latter initially and at 5 years. When non-insulin-dependent patients were grouped according to systolic blood pressure, those with readings above 160 mm Hg had significantly more severe retinopathy than those with readings below 140 mm Hg. Blood pressures initially and at 3 years were not significantly different between patients who received photocoagulation (five with insulin-dependent and six with non-insulin-dependent diabetes and those who did not in either group. There was significant correlation between systolic blood pressure and severity of retinopathy in patients with non-insulin-dependent disease, but the change in severity of retinopathy at 5 years did not correlate with blood pressure in either group.
一项回顾性5年研究调查了48例非胰岛素依赖型糖尿病患者和38例胰岛素依赖型糖尿病患者的血压与轻度背景性视网膜病变的严重程度及进展之间的关系。这些患者自初次就诊起至少3年未接受任何一只眼睛的治疗。所有患者每年都进行包括眼底照相在内的医学和眼科检查。使用哈默史密斯分级系统根据眼底照片评估视网膜病变。非胰岛素依赖型糖尿病患者的初始平均收缩压和舒张压（毫米汞柱）（149/88）显著高于胰岛素依赖型糖尿病患者（129/81）。前者最初及5年后的视网膜病变明显比后者严重。当根据收缩压对非胰岛素依赖型患者进行分组时，收缩压读数高于160毫米汞柱的患者视网膜病变明显比读数低于140毫米汞柱的患者严重。接受光凝治疗的患者（5例胰岛素依赖型和6例非胰岛素依赖型糖尿病患者）与未接受光凝治疗的两组患者在初始及3年时的血压无显著差异。非胰岛素依赖型疾病患者的收缩压与视网膜病变严重程度之间存在显著相关性，但两组患者5年时视网膜病变严重程度的变化与血压均无相关性。
