Mbwambo Orgeness J, Lyatuu Moses, Ngocho Geofrey, Abdallah Khadija, Godfrey Patricia, Ngowi Bartholomeo N, Mremi Alex, Malindisa Evangelista, Amour Maryam, Ngocho James, Balandya Emmanuel, Kwesigabo Gideon, Manongi Rachel, Kidenya Benson R, Mshana Stephen E, Lyamuya Eligius F, Sunguya Bruno F, Bartlett John, Mmbaga Blandina Theophil, Mteta Alfred K
Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Department of Urology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Front Urol. 2023 Sep 13;3:1238293. doi: 10.3389/fruro.2023.1238293. eCollection 2023.
The extent of the burden of erectile dysfunction and its associated factors remains unclear. The aim of this study was to investigate the factors associated with ED and its prevalence among MLHIV in northern Tanzania.
A hospital-based, multi-center, cross-sectional study was conducted on MLHIV aged 18 years and above in northern Tanzania.
The risk factors for ED and the prevalence of such risk factors among MLHIV was assessed and evaluated through a multivariate logistic regression analysis adjusted for depression symptoms using the Patient Health Questionnaire-9 (PHQ9) scale; anxiety disorders using the Generalized Anxiety Disorder Assessment (GAD-7); ART adherence; viral load; initial regimen date; ART regimen; and sexual risk behaviors.
Data for 366 participants with a median age of 50 years (IQR 38-57 years) were available for analysis. Approximately three in four (74.6%) MLHIV had ED (of any severity), whereas 37.7% had mild ED. The majority (96.5%) of the participants had low testosterone, two in three (66.7%) had depressive symptoms, and close to half of the participants (48.4%) had anxiety. Age, lack of engagement in vigorous physical activity, depression, and self-reported good adherence to antiretroviral therapy (ART) were associated with ED in a multivariate logistic regression analysis (=0.004, =0.006, =0.07, =0.006, and =0.004, respectively).
There is a high prevalence of ED among MLHIV in northern Tanzania. Erectile dysfunction should be regarded as one of the comorbidities associated with HIV and should be routinely screened for among MLHIV in CTC clinics.
勃起功能障碍的负担程度及其相关因素仍不明确。本研究的目的是调查坦桑尼亚北部感染艾滋病毒的成年男性中与勃起功能障碍相关的因素及其患病率。
在坦桑尼亚北部对18岁及以上感染艾滋病毒的成年男性进行了一项基于医院的多中心横断面研究。
通过使用患者健康问卷-9（PHQ9）量表对抑郁症状进行调整、使用广泛性焦虑症评估量表（GAD-7）对焦虑症进行调整、评估抗病毒治疗依从性、病毒载量、初始治疗方案日期、抗病毒治疗方案以及性风险行为的多变量逻辑回归分析，评估并分析了感染艾滋病毒的成年男性勃起功能障碍的危险因素及其此类危险因素的患病率。
共有366名参与者的数据可供分析，他们的年龄中位数为50岁（四分位间距为38 - 57岁）。大约四分之三（74.6%）的感染艾滋病毒的成年男性患有勃起功能障碍（任何严重程度），而37.7%患有轻度勃起功能障碍。大多数参与者（96.5%）睾酮水平较低，三分之二（66.7%）有抑郁症状，近一半参与者（48.4%）有焦虑症状。在多变量逻辑回归分析中，年龄、缺乏剧烈体育活动、抑郁以及自我报告的对抗逆转录病毒疗法（ART）的良好依从性与勃起功能障碍相关（分别为=0.004、=0.006、=0.07、=0.006和=0.004）。
坦桑尼亚北部感染艾滋病毒的成年男性中勃起功能障碍的患病率很高。勃起功能障碍应被视为与艾滋病毒相关的合并症之一，在综合治疗中心诊所应对感染艾滋病毒的成年男性进行常规筛查。
