抗体分泌细胞的体细胞遗传学：克隆多样化研究及细胞融合分析 - Suppr

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超能文献

Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.

作者信息

Milstein C, Adetugbo K, Cowan N J, Köhler G, Secher D S, Wilde C D

出版信息

Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:793-803. doi: 10.1101/sqb.1977.041.01.090.

DOI:10.1101/sqb.1977.041.01.090

PMID:408078

Abstract

摘要

相似文献

Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.抗体分泌细胞的体细胞遗传学：克隆多样化研究及细胞融合分析

Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:793-803. doi: 10.1101/sqb.1977.041.01.090.

A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.一种新的小鼠骨髓瘤细胞系，该细胞系已丧失免疫球蛋白表达，但可用于构建分泌抗体的杂交细胞系。

J Immunol. 1979 Oct;123(4):1548-50.

Clonal competition and stability of hybrid myelomas of mouse and rat origin.小鼠和大鼠来源的杂交骨髓瘤的克隆竞争与稳定性

Transplant Proc. 1980 Sep;12(3):371-5.

A human myeloma cell line that does not express immunoglobulin but yields a high frequency of antibody-secreting hybridomas.一种不表达免疫球蛋白但能产生高频率抗体分泌杂交瘤的人骨髓瘤细胞系。

J Immunol. 1982 Jul;129(1):406-12.

Regulation of immunoglobulin expression in mouse myeloma cells.小鼠骨髓瘤细胞中免疫球蛋白表达的调控

Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:781-91. doi: 10.1101/sqb.1977.041.01.089.

Somatic variants in mouse myeloma and hybridoma cell lines.小鼠骨髓瘤和杂交瘤细胞系中的体细胞变异。

Transplant Proc. 1980 Sep;12(3):439-42.

The identification of mouse myeloma cells which have undergone mutations in immunoglobulin production.已在免疫球蛋白产生方面发生突变的小鼠骨髓瘤细胞的鉴定。

Soc Gen Physiol Ser. 1974;29:233-44.

Letter: Fusion of two immunoglobulin-producing myeloma cells.信件：两个产生免疫球蛋白的骨髓瘤细胞的融合。

Nature. 1973 Jul 6;244(5410):42-3. doi: 10.1038/244042a0.

Monoclonal antibodies. A new technique for producing serologic reagents.单克隆抗体。一种生产血清学试剂的新技术。

N Engl J Med. 1981 May 28;304(22):1344-9. doi: 10.1056/NEJM198105283042208.

Clinical significance of immunoglobulin-secreting cells in the peripheral blood in patients with multiple myeloma.多发性骨髓瘤患者外周血中免疫球蛋白分泌细胞的临床意义

Scand J Immunol. 1981 Aug;14(2):99-108. doi: 10.1111/j.1365-3083.1981.tb00189.x.

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Mutations affecting the structure and function of immunoglobulin M.影响免疫球蛋白M结构与功能的突变

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Membrane-bound ribosomes of myeloma cells. VI. Initiation of immunoglobulin mRNA translation occurs on free ribosomes.骨髓瘤细胞膜结合核糖体。VI. 免疫球蛋白mRNA翻译起始于游离核糖体。

J Cell Biol. 1981 Jan;88(1):42-50. doi: 10.1083/jcb.88.1.42.

Secretion of either of a pair of immunoglobulins, IgM or IgX, in somatic hybrid cells derived by fusion of a B-cell lymphoma cell line carrying both immunoglobulin isotypes.通过融合携带两种免疫球蛋白同种型的B细胞淋巴瘤细胞系所产生的体细胞杂交细胞中，分泌一对免疫球蛋白（IgM或IgX）中的任何一种。

Immunogenetics. 1980 Jul;11(1):7-19. doi: 10.1007/BF01567765.

Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas.大鼠/小鼠杂交骨髓瘤中大鼠免疫球蛋白的染色体分离与表达

Immunogenetics. 1980;10(2):125-31. doi: 10.1007/BF01561561.

Loss of antibody production accompanied by chromosome loss in a cloned hybrid line secreting antibodies to sheep red blood cells.在一个分泌抗绵羊红细胞抗体的克隆杂交细胞系中，抗体产生能力丧失并伴有染色体丢失。

Experientia. 1985 Jan 15;41(1):88-9. doi: 10.1007/BF02005890.

Derivation and diversification of monoclonal antibodies.单克隆抗体的衍生与多样化。

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Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.前B细胞系中免疫球蛋白重链基因座的高突变

Proc Natl Acad Sci U S A. 1985 Jan;82(2):479-82. doi: 10.1073/pnas.82.2.479.

Human hybrid immunoglobulin M containing immunoglobulin A.含免疫球蛋白A的人杂交免疫球蛋白M

In Vitro Cell Dev Biol. 1988 Jun;24(6):505-10. doi: 10.1007/BF02629083.

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