文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

使用经颅交流电刺激(tACS)调节与食物渴望相关的神经振荡:一项随机假对照试验的研究方案

Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial.

作者信息

Ljubisavljevic Milos, King Fransina C, Ismail Fatima Yousif, Statsenko Yauhen, Bashir Shahid, Abdullah Osama, Rokers Bas

机构信息

Department of Physiology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University, Al Ain, United Arab Emirates.

ASPIRE Precision Medicine Research Institute Abu Dhabi, United Arab Emirates University, Al Ain, United Arab Emirates.

出版信息

Front Hum Neurosci. 2025 Jul 30;19:1612062. doi: 10.3389/fnhum.2025.1612062. eCollection 2025.


DOI:10.3389/fnhum.2025.1612062
PMID:40808810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12343517/
Abstract

INTRODUCTION: Food addiction is characterized by heightened craving and impaired inhibitory control, contributing to compulsive eating and obesity. Existing behavioral and pharmacological interventions often fail to achieve lasting effects. Transcranial alternating current stimulation (tACS), by modulating neural oscillations and connectivity, offers a novel, non-invasive approach for regulating craving-related neural circuits. OBJECTIVES: This study aims to evaluate the effects of fixed-frequency tACS targeting the dorsal lateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and insula on food cravings, inhibitory control, and related neural oscillations. The trial will assess whether tACS can reduce craving intensity and enhance inhibitory performance in individuals with varying degrees of food addiction severity. METHODS: We will conduct a randomized, double-blind, sham-controlled trial involving 175 participants aged 20-55 years, stratified by food addiction status (FA+ vs. FA-) using the Yale Food Addiction Scale (YFAS 2.0). Participants will receive tACS at alpha (10 Hz) or theta (6 Hz) frequency over the DLPFC, ACC, or insula for seven consecutive days. Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) will be conducted pre- and post-intervention. Primary outcomes include changes in craving intensity and inhibitory control. Secondary outcomes include alterations in neural oscillations and functional connectivity. DISCUSSION: We hypothesize that theta-tACS over the ACC and insula will enhance inhibitory control and interoceptive awareness, while alpha-tACS over the DLPFC will improve top-down regulatory processes. This protocol aims to clarify the neural mechanisms underlying food cravings and evaluate tACS as a promising intervention for compulsive eating.

摘要

引言:食物成瘾的特征是强烈的渴望和抑制控制受损,导致强迫性进食和肥胖。现有的行为和药物干预往往无法取得持久效果。经颅交流电刺激(tACS)通过调节神经振荡和连接性,提供了一种调节与渴望相关神经回路的新颖、非侵入性方法。 目的:本研究旨在评估针对背外侧前额叶皮层(DLPFC)、前扣带回皮层(ACC)和脑岛的固定频率tACS对食物渴望、抑制控制及相关神经振荡的影响。该试验将评估tACS是否能降低不同程度食物成瘾严重程度个体的渴望强度并增强抑制表现。 方法:我们将进行一项随机、双盲、假对照试验,纳入175名年龄在20至55岁之间的参与者,使用耶鲁食物成瘾量表(YFAS 2.0)按食物成瘾状态(FA+与FA-)进行分层。参与者将在DLPFC、ACC或脑岛接受连续七天的α(10Hz)或θ(6Hz)频率的tACS。干预前后将进行脑电图(EEG)和功能磁共振成像(fMRI)检查。主要结局包括渴望强度和抑制控制的变化。次要结局包括神经振荡和功能连接的改变。 讨论:我们假设,ACC和脑岛的θ-tACS将增强抑制控制和内感受觉意识,而DLPFC的α-tACS将改善自上而下的调节过程。本方案旨在阐明食物渴望背后的神经机制,并评估tACS作为一种有前景的强迫性进食干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a507/12343517/e7cb8576b77a/fnhum-19-1612062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a507/12343517/e7cb8576b77a/fnhum-19-1612062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a507/12343517/e7cb8576b77a/fnhum-19-1612062-g001.jpg

相似文献

[1]
Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial.

Front Hum Neurosci. 2025-7-30

[2]
Prescription of Controlled Substances: Benefits and Risks

2025-1

[3]
Individualised Alpha-tACS for Modulating Pain Perception and Neural Oscillations: A Sham-Controlled Study in Healthy Participants.

Eur J Pain. 2025-8

[4]
Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial.

JMIR Res Protoc. 2023-11-6

[5]
Study protocol for a multi-session randomized sham-controlled trial of PCC- and amygdala-targeted neurofeedback for the treatment of PTSD.

BMC Psychiatry. 2025-7-15

[6]
Analgesic aftereffects of alpha high-definition transcranial alternating current stimulation over the DLPFC during experimental pain.

Neuroimage. 2025-6-16

[7]
Brain-Computer-Brain system for individualized transcranial alternating current stimulation with concurrent EEG recording: a healthy subject pilot study.

Annu Int Conf IEEE Eng Med Biol Soc. 2024-7

[8]
Trialing addiction neurocircuitry targets and directionality of brain stimulation effects: A deep TMS/fMRI trial in people with alcohol use disorder.

Contemp Clin Trials Commun. 2025-6-30

[9]
Enhancing prefrontal modulation by phase-locking intermittent theta burst stimulation to a concurrent transcranial alternating current stimulation.

Imaging Neurosci (Camb). 2025-1-3

[10]
Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditory hallucinations.

Transl Psychiatry. 2025-1-30

本文引用的文献

[1]
Preclinical insights into gamma-tACS: foundations for clinical translation in neurodegenerative diseases.

Front Neurosci. 2025-3-12

[2]
Randomized Controlled Trial of Bifrontal Transcranial Direct Current Stimulation on Craving in Alcohol Use Disorder.

Indian J Psychol Med. 2024-1-24

[3]
Food Addiction.

Brain Sci. 2024-9-24

[4]
Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial.

Front Neurosci. 2023-12-21

[5]
An electroencephalographic signature predicts craving for methamphetamine.

Cell Rep Med. 2024-1-16

[6]
A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.

Neuropsychopharmacology. 2024-3

[7]
Editorial: Neurobiology of food addiction.

Front Behav Neurosci. 2023-11-6

[8]
From Pleasure to Pathology: Understanding the Neural Basis of Food Addiction in the Context of Obesity.

Chirurgia (Bucur). 2023-8

[9]
The Relationship between Trait Impulsivity and Everyday Executive Functions among Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Negative Emotions.

J Diabetes Res. 2023

[10]
Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions.

Mol Psychiatry. 2023-12

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索