Siedlecka Dominika, Ludziejewska Aleksandra, Bielawska Lena, Baszczuk Aleksandra, Gawron Marta, Danielewicz Mikołaj, Wysocka Ewa
Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
Laboratory, Miedzyrzecz Hospital, Miedzyrzecz, Poland.
Front Public Health. 2025 Aug 5;13:1648937. doi: 10.3389/fpubh.2025.1648937. eCollection 2025.
Exposure to the SARS-CoV-2 activates two forms of active immunity: natural appearance after infection and vaccine induced immunity.
We have conducted a retrospective analysis the serum concentration of IgG antibodies against SARS-CoV-2 in the population of Poznan University Clinical Hospital (PH) and Miedzyrzecz Hospital (MH) from 2021 to 2023.
In the entire study population ( = 3,104), as well as in the PH ( = 1,746) and MH ( = 1,358) groups, no significant differences in age ( = 0.1455) or BAU/ml values ( = 0.7874) between women and men were found. Significant differences were observed between the 18-35 and 36-60 age subgroups compared to the >60 age subgroup in the entire study population ( = 0.0022; = 0.0001) and the PH group ( = 0.0176; = 0.0003). In the MH group, significant differences were seen between the 18-35 and 36-60 age subgroups ( = 0.0305), as well as between the 18-35 and >60 age subgroups ( = 0.0050). A positive correlation was found between the number of infections and the number of tests conducted in each study group (R = 0.59, = 0.0016).
The concentration of anti-SARS-CoV-2 IgG antibodies is significantly higher in individuals over 60 years old compared to those in the 18-35 and 36-60 age groups. The correlations between age and antibody levels were significant but weak, suggesting that age should not be considered the main factor in predicting the immune response after vaccination or COVID-19 infection. Both women and men presented a similar immune responses to SARS-CoV-2 during the pandemic. Additionally, the number of infections within a specific time period influenced the number of individuals tested for anti-SARS-CoV-2 antibodies.
接触严重急性呼吸综合征冠状病毒2（SARS-CoV-2）会激活两种主动免疫形式：感染后的自然出现和疫苗诱导的免疫。
我们对波兹南大学临床医院（PH）和米德济热茨医院（MH）2021年至2023年人群中抗SARS-CoV-2 IgG抗体的血清浓度进行了回顾性分析。
在整个研究人群（n = 3104）以及PH组（n = 1746）和MH组（n = 1358）中，未发现女性和男性在年龄（p = 0.1455）或BAU/ml值（p = 0.7874）上有显著差异。在整个研究人群（p = 0.0022；p = 0.0001）和PH组（p = 0.0176；p = 0.0003）中，与60岁以上年龄亚组相比，18 - 35岁和36 - 60岁年龄亚组之间观察到显著差异。在MH组中，18 - 35岁和36 - 60岁年龄亚组之间（p = 0.0305）以及18 - 35岁和60岁以上年龄亚组之间（p = 0.0050）存在显著差异。在每个研究组中，感染次数与检测次数之间发现正相关（R = 0.59，p = 0.0016）。
与18 - 35岁和36 - 60岁年龄组相比，60岁以上个体的抗SARS-CoV-2 IgG抗体浓度显著更高。年龄与抗体水平之间的相关性显著但较弱，这表明年龄不应被视为预测疫苗接种或新冠病毒感染后免疫反应的主要因素。在疫情期间，男性和女性对SARS-CoV-2均呈现出相似的免疫反应。此外，特定时间段内的感染次数影响了检测抗SARS-CoV-2抗体的个体数量。
