Haghshenas Niloufar, Ghoreishy Seyed Mojtaba, Noormohammadi Morvarid, Hosseini-Baharanchi Fatemeh Sadat, Shidfar Farzad
Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 Aug 28;15(1):31682. doi: 10.1038/s41598-025-17578-x.
In recent times, research has delved into the impact of dietary elements on alleviating menopausal symptoms. We endeavored to examine the correlation between the modified Mediterranean diet score (mMDS) and quality of life, menopausal symptoms, discriminative ability and determination of the optimal cut-off point. A total of one hundred forty-nine postmenopausal females were selected to participate in the cross-sectional study from June 2021 to June 2022. Upon completion of data collection through interviews, the relevant variables were calculated. The assessment of participants' food consumption in the preceding year was conducted using a 117-item food frequency questionnaire. postmenopausal women who were referred to healthcare clinics in Lar. The participants were exclusively women aged 40 and above who had not undergone a menstrual cycle for a minimum of 12 months. We observed that mMDS associated with the severity of sexual and vasomotor symptoms. The third tertile of mMDS had a significantly lower odds ratio for severe to moderate sexual (OR: 0.17; 95% CI: 0.068, 0.450) and vasomotor (OR: 0.20; 95% CI: 0.064, 0.658) symptoms compared to the first tertile. Also, mMDS showed significant discriminative ability in identifying women with severe to moderate poor quality of life (AUC = 0.997, 95% CI = 0.988-1.000; p-value = 0.001), vasomotor (AUC = 0.727, p-value < 0.001), psychological (AUC = 0.867, p-value < 0.001), physical (AUC = 0.934, p-value < 0.001) and sexual symptoms (AUC = 0.753; p-value < 0.001). There is promising yet incongruous data indicating the potential of the Mediterranean diet in the management of vasomotor symptoms in menopausal women. Further comprehensive, extended research is essential for the development of precise dietary recommendations.
近年来，研究深入探讨了饮食因素对缓解更年期症状的影响。我们致力于研究改良地中海饮食评分（mMDS）与生活质量、更年期症状、鉴别能力以及最佳切点确定之间的相关性。2021年6月至2022年6月，共选取了149名绝经后女性参与这项横断面研究。通过访谈完成数据收集后，计算相关变量。使用一份包含117个条目的食物频率问卷对参与者前一年的食物消费情况进行评估。这些绝经后女性被转诊至拉尔的医疗诊所。参与者均为40岁及以上且至少12个月没有月经周期的女性。我们观察到mMDS与性症状和血管舒缩症状的严重程度相关。与第一三分位数相比，mMDS的第三三分位数出现严重至中度性症状（OR：0.17；95%CI：0.068，0.450）和血管舒缩症状（OR：0.20；95%CI：0.064，0.658）的比值比显著更低。此外，mMDS在识别严重至中度生活质量差（AUC = 0.997，95%CI = 0.988 - 1.000；p值 = 0.001）、血管舒缩（AUC = 0.727，p值 < 0.001）、心理（AUC = 0.867，p值 < 0.001）、身体（AUC = 0.934，p值 < 0.001）和性症状（AUC = 0.753；p值 < 0.001）的女性方面显示出显著的鉴别能力。有前景但不一致的数据表明地中海饮食在管理绝经后女性血管舒缩症状方面具有潜力。进一步全面、深入的研究对于制定精确的饮食建议至关重要。
