Beaurain G, Niaudet P
Scand J Immunol. 1985 Dec;22(6):603-10. doi: 10.1111/j.1365-3083.1985.tb01922.x.
The proliferative response of highly purified human peripheral blood or tonsil lymphocytes in the presence of soluble protein A (SpA) was investigated. SpA was shown to be a potent mitogen for T lymphocytes from peripheral blood or tonsils. Conversely, the non-T lymphocyte population from peripheral blood responded poorly to SpA, and SpA did not stimulate non-T lymphocytes from tonsils. The addition of mitomycin-treated T lymphocytes from peripheral blood enhanced the response of blood non-T lymphocytes to protein A. This effect was not found when non-T lymphocytes isolated from tonsils were cultured with mitomycin-treated T lymphocytes. The proliferative response of unseparated cells or purified lymphocyte populations was enhanced when adherent cells were added to the cultures. It is concluded that the soluble form of protein A activates mainly T lymphocytes and does not induce B lymphocyte proliferation.
研究了在可溶性蛋白A（SpA）存在下高度纯化的人外周血或扁桃体淋巴细胞的增殖反应。结果表明，SpA是外周血或扁桃体T淋巴细胞的有效促有丝分裂原。相反，外周血中的非T淋巴细胞群体对SpA反应不佳，SpA也不刺激扁桃体中的非T淋巴细胞。添加经丝裂霉素处理的外周血T淋巴细胞可增强血液中非T淋巴细胞对蛋白A的反应。当从扁桃体分离的非T淋巴细胞与经丝裂霉素处理的T淋巴细胞一起培养时，未发现这种效应。当将贴壁细胞添加到培养物中时，未分离细胞或纯化淋巴细胞群体的增殖反应增强。得出的结论是，蛋白A的可溶性形式主要激活T淋巴细胞，不诱导B淋巴细胞增殖。
