Afkhami Farzaneh, Elahy Sadaf, Mahmoudi-Nahavandi Alireza
DDS, MSc, Department of Endodontics, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
DDS, New York University, New York, US.
J Clin Exp Dent. 2017 Jul 1;9(7):e842-e847. doi: 10.4317/jced.53743. eCollection 2017 Jul.
Optimal antibacterial efficacy of intracanal medicaments containing silver nanoparticles (Ag-NPs) has been well documented. However, concerns remain regarding the effect of Ag-NPs on tooth color. This study aimed to assess the effects of calcium hydroxide (CH) mixed with Ag-NPs as intracanal medicaments on tooth color. The effect of location of application of medicament on the degree of discoloration was evaluated as well.
Fifty extracted single-rooted, single-canal human teeth with straight roots, no caries, no cracks or fractures were collected and accessed. After cleaning and shaping of the root canals, the teeth were randomly divided into two experimental groups (n=20) with CH and CH plus Ag-NPs as intracanal medicaments and a control group of saline (n=10). Experimental groups were randomly divided into two equal subgroups of A, where medicament was applied below the cemento enamel junction (CEJ) and B where the medicament was applied to the root canal and pulp chamber. Color change (ΔE) was assessed using a spectrophotometer in CIELAB system at five time points of beforemedicaments application (T0), immediately medicaments placement (T1), one week (T2), one month (T3) and three months (T4) after the application of medicaments. Data were analyzed using two-way and three-way ANOVA.
Color change in Ag-NPs plus CH and CH groups was not significantly different at any time point (=0.23). Increased exposure time in both groups did not increase the ΔE ( >0.05). Significant differences were noted in ΔE between subgroups A and B (<0.05).
Addition of Ag-NPs to CH caused no significant change in tooth color compared to the application of CH alone. However, its use must be limited to the root canal space only. Silver nanoparticles, color change, calcium hydroxide, spectrophotometry, intracanal medicament.
含银纳米颗粒（Ag-NPs）的根管内药物的最佳抗菌效果已有充分记录。然而，Ag-NPs对牙齿颜色的影响仍存在担忧。本研究旨在评估氢氧化钙（CH）与Ag-NPs混合作为根管内药物对牙齿颜色的影响。还评估了药物应用位置对变色程度的影响。
收集50颗拔除的单根、单根管、牙根直、无龋、无裂纹或骨折的人牙并进行开髓。根管清理和成形后，将牙齿随机分为两个实验组（n=20），分别使用CH和CH加Ag-NPs作为根管内药物，以及一个生理盐水对照组（n=10）。实验组随机分为两个相等的亚组A和B，A组药物应用于牙骨质牙釉质界（CEJ）下方，B组药物应用于根管和髓腔。在药物应用前（T0）、药物放置后即刻（T1）、药物应用后1周（T2）、1个月（T3）和3个月（T4）这五个时间点，使用CIELAB系统中的分光光度计评估颜色变化（ΔE）。数据采用双向和三向方差分析进行分析。
在任何时间点，Ag-NPs加CH组和CH组的颜色变化均无显著差异（P=0.23）。两组中暴露时间的增加均未增加ΔE（P>0.05）。亚组A和B之间的ΔE存在显著差异（P<0.05）。
与单独应用CH相比，向CH中添加Ag-NPs不会导致牙齿颜色发生显著变化。然而，其使用必须仅限于根管空间。银纳米颗粒、颜色变化、氢氧化钙、分光光度法、根管内药物。
