Lu Miao, Zhang Yanan, Zhang Yang, Yuan Xulei, Zhang Tingwei, Song Jinlin
Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher Education, and Stomatological Hospital of Chongqing Medical University, Chongqing, China.
J Oral Microbiol. 2025 Sep 1;17(1):2554381. doi: 10.1080/20002297.2025.2554381. eCollection 2025.
This study aims to explore the mechanisms of the detrimental effects of postmenopausal osteoporosis (PMO) on periodontitis.
An ovariectomized (OVX) rat model was established to investigate the effects of PMO on alveolar bone homeostasis and periodontal inflammation. Chlorhexidine digluconate (CHX) was administered to rats with OVX - periodontitis to ascertain the involvement of the oral microbiota in the influence of PMO on periodontitis. Finally, oral microbiota transplantation was conducted to examine the oral microbiota's pathogenicity.
OVX rats exhibited increased periodontal trabecular bone resorption and inflammation. In addition, depletion of the oral microbiota by CHX decreased the alveolar bone destruction in OVX - periodontitis rats. Furthermore, 16S rRNA gene sequencing demonstrated that PMO changes the composition of the oral microbiota. Finally, oral microbiota transplantation indicated that PMO enhanced the oral microbiota's pathogenicity.
PMO detrimentally affects periodontitis by increasing periodontal inflammation and the pathogenicity of the oral microbiota, which provides a mechanistic understanding of how PMO affects periodontitis and highlights the necessity of more regular monitoring of the oral microbiota in PMO patients.
本研究旨在探讨绝经后骨质疏松症（PMO）对牙周炎产生有害影响的机制。
建立去卵巢（OVX）大鼠模型，以研究PMO对牙槽骨稳态和牙周炎症的影响。对患有OVX-牙周炎的大鼠给予葡萄糖酸氯己定（CHX），以确定口腔微生物群在PMO对牙周炎影响中的作用。最后，进行口腔微生物群移植以检测口腔微生物群的致病性。
OVX大鼠表现出牙周小梁骨吸收增加和炎症。此外，CHX清除口腔微生物群可减少OVX-牙周炎大鼠的牙槽骨破坏。此外，16S rRNA基因测序表明PMO改变了口腔微生物群的组成。最后，口腔微生物群移植表明PMO增强了口腔微生物群的致病性。
PMO通过增加牙周炎症和口腔微生物群的致病性对牙周炎产生有害影响，这为理解PMO如何影响牙周炎提供了机制，并强调了对PMO患者更定期监测口腔微生物群的必要性。
