Yeshanew Solomon, Kendie Fasil Adugna, Nibret Endalkachew, Atenafu Getnet
Department of Biology, College of Science, Bahir Dar University, Bahir Dar, Ethiopia.
Department of Biology, Debre Markos University, Debre Markos, Ethiopia.
J Trop Med. 2025 Aug 31;2025:7891775. doi: 10.1155/jotm/7891775. eCollection 2025.
, the primary malaria vector in Ethiopia, exhibits diverse feeding behaviors influenced by geography, climate, and control strategies. Understanding its blood-feeding preference is crucial for devising effective interventions. This study aimed to conduct a systematic review and meta-analysis of existing evidence on human blood index (HBI) in Ethiopia. A comprehensive search of multiple electronic databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Study quality was assessed using criteria adopted from the Joanna Briggs Institute (JBI) appraisal checklist. Data were analyzed using Stata Version 17, employing a random-effects model to estimate the pooled HBI at 95% confidence interval (CI). Subgroup analysis and meta-regression were performed based on regions and mosquito collection methods. Heterogeneity was assessed using the test. A total of 19 studies published from 1997 to 2023 were included, encompassing 12,794 blood-fed . The meta-analysis revealed a pooled HBI of 37.18% (95% CI: 21.26-44.28). Subgroup analysis showed regional variation, with the highest HBI reported in Mixed Region 3 (covering Afar, Oromia, and the Amhara Regional States) at 64.02% (95% CI: 61.78-66.25), and the lowest in the Amhara Regional State at 7.53% (95% CI: -1.58-16.65). Temporal analysis indicated fluctuations over time, with the highest HBI reported in 2014 (70.62%, 95% CI: 68.72-72.46) and the lowest in 2021 (0%, 95% CI: 0.00-1.30). The present study found that in Ethiopia exhibits a moderate preference for human blood, with a pooled HBI of 37.18%. However, significant variation exists across regions and over time. Continuous surveillance and further research are needed to explore the underlying factors influencing HBI and to guide evidence-based malaria prevention and control strategies.
在埃塞俄比亚，主要的疟疾传播媒介表现出受地理、气候和控制策略影响的多样摄食行为。了解其吸血偏好对于制定有效的干预措施至关重要。本研究旨在对埃塞俄比亚人类血液指数（HBI）的现有证据进行系统评价和荟萃分析。按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，对多个电子数据库进行了全面检索。使用乔安娜·布里格斯研究所（JBI）评估清单采用的标准对研究质量进行评估。使用Stata 17版本进行数据分析，采用随机效应模型在95%置信区间（CI）估计合并的HBI。基于地区和蚊虫采集方法进行亚组分析和荟萃回归。使用 检验评估异质性。共纳入1997年至2023年发表的19项研究，涵盖12,794只吸血 。荟萃分析显示合并的HBI为37.18%（95%CI：21.26 - 44.28）。亚组分析显示存在地区差异，混合地区3（涵盖阿法尔州、奥罗米亚州和阿姆哈拉州）报告的HBI最高，为64.02%（95%CI：61.78 - 66.25），阿姆哈拉州最低，为7.53%（95%CI： - 1.58 - 16.65）。时间分析表明随时间波动，2014年报告的HBI最高（70.62%，95%CI：68.72 - 72.46），2021年最低（0%，95%CI：0.00 - 1.30）。本研究发现，埃塞俄比亚的 对人类血液表现出中等偏好，合并的HBI为37.18%。然而，地区间和随时间存在显著差异。需要持续监测和进一步研究以探索影响HBI的潜在因素，并指导基于证据的疟疾预防和控制策略。
