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成人及小儿阻塞性睡眠呼吸暂停患者的麻醉管理

Anesthesiologic Management of Adult and Pediatric Patients with Obstructive Sleep Apnea.

作者信息

La Via Luigi, Iannella Giannicola, Pace Annalisa, Magliulo Giuseppe, Cuttone Giuseppe, Modica Rodolfo, Lentini Mario, Botto Carmelo Giancarlo, Paternò Daniele Salvatore, Sorbello Massimiliano, Lechien Jerome R, Maniaci Antonino

机构信息

Department of Anaesthesia and Intensive Care, University Hospital Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.

Department of Otolaryngology-Head Neck Surgery, La Sapienza University, 00161 Rome, Italy.

出版信息

Healthcare (Basel). 2025 Sep 1;13(17):2183. doi: 10.3390/healthcare13172183.

Abstract

Obstructive sleep apnea (OSA) is a prevalent yet underdiagnosed condition that significantly increases perioperative morbidity and mortality in both adult and pediatric populations. Its pathophysiology, involving intermittent upper airway obstruction during sleep, poses unique challenges for anesthesiologists due to altered airway anatomy, increased sensitivity to sedatives, and unpredictable ventilatory responses. This comprehensive review summarizes current evidence on the anesthesiologic management of OSA patients, focusing on preoperative screening, risk stratification, intraoperative considerations, and postoperative care. Effective management of OSA requires a multidisciplinary and individualized approach. Preoperative assessment should include validated tools such as STOP-Bang or polysomnography when available. Intraoperative strategies include careful titration of sedatives and opioids, airway protection techniques, and use of short-acting agents. Pediatric patients present specific anatomical and physiological risks, particularly in adenotonsillectomy cases. Postoperative monitoring, especially in the first 24 h, is critical to detect respiratory depression, with CPAP therapy often beneficial in selected patients. Recognizing and appropriately managing OSA in surgical candidates is crucial for improving outcomes and reducing complications. Anesthesiologists should tailor perioperative strategies to the severity of OSA, age group, and type of surgery. Future research should aim to refine predictive tools and establish standardized protocols, particularly in pediatric populations.

摘要

阻塞性睡眠呼吸暂停(OSA)是一种普遍存在但诊断不足的病症,它显著增加了成人和儿童围手术期的发病率和死亡率。其病理生理学涉及睡眠期间间歇性上呼吸道阻塞,由于气道解剖结构改变、对镇静剂敏感性增加以及不可预测的通气反应,给麻醉医生带来了独特的挑战。这篇综述总结了关于OSA患者麻醉管理的当前证据,重点关注术前筛查、风险分层、术中注意事项和术后护理。OSA的有效管理需要多学科和个体化的方法。术前评估应包括使用经过验证的工具,如STOP-Bang问卷,如有条件可进行多导睡眠图检查。术中策略包括谨慎滴定镇静剂和阿片类药物、气道保护技术以及使用短效药物。儿科患者存在特定的解剖和生理风险,尤其是在腺样体扁桃体切除术病例中。术后监测,特别是在术后24小时内,对于检测呼吸抑制至关重要,持续气道正压通气(CPAP)治疗通常对部分患者有益。识别并适当管理手术患者中的OSA对于改善预后和减少并发症至关重要。麻醉医生应根据OSA的严重程度、年龄组和手术类型调整围手术期策略。未来的研究应致力于完善预测工具并建立标准化方案,特别是在儿科人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d588/12428584/d1d737a713d1/healthcare-13-02183-g001.jpg

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