Deng Kunqiang, Chen Kunfeng, Huang Sai, Li Jinkai, Liu Zongming
School of Material Science and Engineering, University of Jinan, Jinan 250022, China.
State Key Laboratory of Crystal Materials, Institute of Novel Semiconductors, Shandong University, Jinan 250100, China.
Materials (Basel). 2025 Aug 22;18(17):3937. doi: 10.3390/ma18173937.
Persistent luminescence nanoparticles (PLNPs) represent a unique class of optical materials. They possess the ability to absorb and store energy from external excitation sources and emit light persistently once excitation terminates. Because of this distinctive property, PLNPs have attracted considerable attention in various areas. Especially in recent years, PLNPs have revealed marked benefits and extensive application potential in fields such as biological detection, imaging, targeted delivery, as well as integrated diagnosis and treatment. Not only do they potently attenuate autofluorescence interference arising from biological tissues, but they also demonstrate superior signal-to-noise ratio and sensitivity in in vivo imaging scenarios. Therefore, regarding the current research, this paper firstly introduces the classification, synthesis methods, and luminescence mechanism of the materials. Subsequently, the research progress of PLNPs in biological detection and imaging and medical treatment in recent years is reviewed. The challenges faced by materials in biomedical applications and the outlook of future development trends are further discussed, which delivers an innovative thought pattern for developing and designing new PLNPs to cater to more practical requirements.
持续发光纳米粒子（PLNPs）是一类独特的光学材料。它们具有从外部激发源吸收和存储能量的能力，并且一旦激发终止就会持续发光。由于这种独特的性质，PLNPs在各个领域都引起了相当大的关注。特别是近年来，PLNPs在生物检测、成像、靶向递送以及综合诊断与治疗等领域显示出显著的优势和广泛的应用潜力。它们不仅能有效减弱生物组织产生的自发荧光干扰，而且在体内成像场景中还表现出卓越的信噪比和灵敏度。因此，针对当前的研究，本文首先介绍了该材料的分类、合成方法和发光机制。随后，综述了近年来PLNPs在生物检测、成像和医学治疗方面的研究进展。进一步讨论了材料在生物医学应用中面临的挑战以及未来发展趋势的展望，这为开发和设计新的PLNPs以满足更多实际需求提供了一种创新的思维模式。
