Sim Hyeonji, An Yoojin, Kim Sung-Soo, Kwon Danbee, Lee Jeongmin, Lee Kichang, Yoon Hakyoung
Department of Veterinary Medical Imaging, College of Veterinary Medicine, Jeonbuk National University-Specialized Campus, Iksan-si, Jeollabuk-do, South Korea.
VIP Animal Medical Center, Seoul, South Korea.
Vet Radiol Ultrasound. 2025 Sep;66(5):e70090. doi: 10.1111/vru.70090.
In this retrospective multicenter study, we aimed to establish the renal cortical thickness-aortic diameter (RCT:Ao) ratio as a diagnostic parameter for detecting feline acute kidney injury or chronic kidney disease (AKI or CKD). This study included bilateral kidneys of 152 normal, 171 CKD, 19 AKI, and 15 acute-on-chronic kidney disease (ACKD) cats. Ultrasonographic measurements were obtained in the midsagittal plane of the kidneys and aorta. Multiple linear regression analysis of RCT, body weight (BW), and body condition score (BCS) revealed a positive correlation of RCT with BW (p < 0.001), but not with BCS (p = 0.343). Multiple linear regression analysis of RCT:Ao ratio, BW, and BCS showed a poor model fit (F value: 0.119). There were significant intergroup differences among the normal, CKD, AKI, and ACKD sub-cohorts (p < 0.001). Compared to normal cats, CKD and AKI cats each had lower and higher RCT:Ao ratio (both p < 0.001), respectively. The RCT:Ao ratio of the ACKD group significantly differed from that in normal and CKD groups (both p < 0.001), but not the AKI group (p = 0.159). Optimal RCT:Ao ratio cutoffs of 1.15 and 1.45 were used to distinguish between the normal and CKD groups (75% sensitivity, 80% specificity) and the normal and AKI groups (90% sensitivity, 89% specificity), respectively. The RCT:Ao ratio was unaffected by the BW and BCS and is a clinically useful diagnostic parameter for feline kidney disease.
在这项回顾性多中心研究中，我们旨在确立肾皮质厚度与主动脉直径（RCT:Ao）之比，作为检测猫急性肾损伤或慢性肾病（AKI或CKD）的诊断参数。本研究纳入了152只正常猫、171只CKD猫、19只AKI猫和15只慢性肾病急性发作（ACKD）猫的双侧肾脏。在肾脏和主动脉的正中矢状平面进行超声测量。对RCT、体重（BW）和体况评分（BCS）进行多元线性回归分析，结果显示RCT与BW呈正相关（p < 0.001），但与BCS无关（p = 0.343）。对RCT:Ao比值、BW和BCS进行多元线性回归分析，结果显示模型拟合度较差（F值：0.119）。正常、CKD、AKI和ACKD亚组之间存在显著的组间差异（p < 0.001）。与正常猫相比，CKD猫和AKI猫的RCT:Ao比值分别较低和较高（均p < 0.001）。ACKD组的RCT:Ao比值与正常组和CKD组均有显著差异（均p < 0.001），但与AKI组无显著差异（p = 0.159）。分别采用1.15和1.45的最佳RCT:Ao比值临界值来区分正常组和CKD组（灵敏度75%，特异度80%）以及正常组和AKI组（灵敏度90%，特异度89%）。RCT:Ao比值不受BW和BCS的影响，是猫肾病临床上有用的诊断参数。
