关于播散性淋球菌感染中淋病奈瑟菌的基因研究。
Genetic studies on Neisseria gonorrhoeae from disseminated gonococcal infections.
作者信息
Mayer L W, Schoolnik G K, Falkow S
出版信息
Infect Immun. 1977 Oct;18(1):165-72. doi: 10.1128/iai.18.1.165-172.1977.
Abstract
Isolates from uncomplicated and disseminated gonococcal infections were analyzed by using deoxyribonucleic acid-mediated transformation. Most pairs of auxotrophs could recombine, producing independent transformants. When the constellation of arginine (Arg), hypoxanthine (Hyx), and uracil (Ura) requirements was present in donor and recipient, no recombination for these traits could be detected. Except for Arg to Hyx, no linkage between Arg, Hyx, Ura, penicillin G sensitivity, and serum resistance could be demonstrated. Some distant linkage of Ura to nalidixic acid and rifampin resistances was found. The data show that the traits associated with disseminated gonococcal infection strains are not closely linked but are identical in all strains, indicating a common origin.
摘要
采用脱氧核糖核酸介导的转化方法对单纯性和播散性淋球菌感染的分离株进行了分析。大多数营养缺陷型菌株对能够重组，产生独立的转化体。当供体和受体中都存在精氨酸（Arg）、次黄嘌呤（Hyx）和尿嘧啶（Ura）需求的组合时，这些性状无法检测到重组现象。除了Arg与Hyx之间，未发现Arg、Hyx、Ura、青霉素G敏感性和血清抗性之间存在连锁关系。发现Ura与萘啶酸和利福平抗性之间存在一些远距离连锁关系。数据表明，与播散性淋球菌感染菌株相关的性状并非紧密连锁，但在所有菌株中是相同的，这表明它们有共同的起源。
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