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2

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Genetic studies on Neisseria gonorrhoeae from disseminated gonococcal infections.关于播散性淋球菌感染中淋病奈瑟菌的基因研究。

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Identification of drug resistance loci in various clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌不同临床分离株中耐药位点的鉴定

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Arginine and pyrimidine biosynthetic defects in Neisseria gonorrhoeae strains isolated from patients.从患者中分离出的淋病奈瑟菌菌株中的精氨酸和嘧啶生物合成缺陷。

J Bacteriol. 1982 Jul;151(1):295-302. doi: 10.1128/jb.151.1.295-302.1982.

2

Identification of a new genetic site (sac-3+) in Neisseria gonorrhoeae that affects sensitivity to normal human serum.在淋病奈瑟菌中鉴定出一个影响对正常人血清敏感性的新基因位点（sac-3+）。

Infect Immun. 1982 Mar;35(3):764-9. doi: 10.1128/iai.35.3.764-769.1982.

3

Genetics of serum resistance in Neisseria gonorrhoeae: the sac-1 genetic locus.淋病奈瑟菌血清抗性的遗传学：sac-1基因座

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Effect of dilution rate on lipopolysaccharide and serum resistance of Neisseria gonorrhoeae grown in continuous culture.稀释率对连续培养的淋病奈瑟菌脂多糖和血清抗性的影响。

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Cloning genes for proline biosynthesis from Neisseria gonorrhoeae: identification by interspecific complementation of Escherichia coli mutants.从淋病奈瑟菌中克隆脯氨酸生物合成基因：通过大肠杆菌突变体的种间互补进行鉴定。

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Pyocin-resistant lipopolysaccharide mutans of Neisseria gonorrhoeae: alterations in sensitivity to normal human serum and polymyxin B.淋病奈瑟菌对绿脓菌素耐药的脂多糖突变体：对正常人血清和多粘菌素B敏感性的改变

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7

Genetic analysis of spontaneous resistance to ampicillin in Neisseria gonorrhoeae.淋病奈瑟菌对氨苄西林自发耐药性的遗传分析。

Antimicrob Agents Chemother. 1985 Jul;28(1):21-7. doi: 10.1128/AAC.28.1.21.

8

A recombinant molecule from a disseminating strain of Neisseria gonorrhoeae that confers serum bactericidal resistance.一种来自播散性淋病奈瑟菌菌株的重组分子，其赋予血清杀菌抗性。

Infect Immun. 1987 Dec;55(12):3017-22. doi: 10.1128/iai.55.12.3017-3022.1987.

9

Characterization of protein I from serum-sensitive and serum-resistant transformants of Neisseria gonorrhoeae.淋病奈瑟菌血清敏感型和血清耐药型转化体中蛋白I的特性分析。

Infect Immun. 1987 Jan;55(1):273-6. doi: 10.1128/iai.55.1.273-276.1987.

10

Protein I: structure, function, and genetics.蛋白质I：结构、功能与遗传学

Clin Microbiol Rev. 1989 Apr;2 Suppl(Suppl):S41-8. doi: 10.1128/CMR.2.Suppl.S41.

本文引用的文献

1

NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。

J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.

2

Low antibiotic resistance of gonococci causing disseminated infection.引起播散性感染的淋球菌抗生素耐药性低。

N Engl J Med. 1973 Jun 7;288(23):1221-2. doi: 10.1056/NEJM197306072882308.

3

Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.淋病奈瑟菌中相关抗生素抗性基因座的遗传图谱分析

J Bacteriol. 1974 Dec;120(3):1284-92. doi: 10.1128/jb.120.3.1284-1292.1974.

4

Development of a defined minimal medium for the growth of Neisseria gonorrhoeae.用于淋病奈瑟菌生长的限定性基础培养基的研发。

Appl Microbiol. 1974 Jul;28(1):70-6. doi: 10.1128/am.28.1.70-76.1974.

5

Neisseria gonorrhoeae auxotyping: differentiation of clinical isolates based on growth responses on chemically defined media.淋病奈瑟菌菌型分类：基于在化学成分明确的培养基上的生长反应对临床分离株进行区分。

Appl Microbiol. 1973 Sep;26(3):223-30. doi: 10.1128/am.26.3.223-230.1973.

6

Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing.淋病奈瑟菌、脑膜炎奈瑟菌和乳糖奈瑟菌在化学成分明确的培养基中的营养特征以及淋病奈瑟菌分型生长需求的应用。

J Infect Dis. 1973 Aug;128(2):178-94. doi: 10.1093/infdis/128.2.178.

7

Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera.引起播散性淋球菌感染的淋球菌对正常人血清的杀菌作用具有抗性。

J Clin Invest. 1976 Nov;58(5):1163-73. doi: 10.1172/JCI108569.

8

Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections.播散性和局限性感染中不典型淋病奈瑟菌的特征

Infect Immun. 1976 May;13(5):1510-6. doi: 10.1128/iai.13.5.1510-1516.1976.

9

Genetic studies on Neisseria gonorrhoeae from disseminated gonococcal infections.关于播散性淋球菌感染中淋病奈瑟菌的基因研究。

Infect Immun. 1977 Oct;18(1):165-72. doi: 10.1128/iai.18.1.165-172.1977.

10

Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection.青霉素敏感性和血清抗性是引起播散性淋球菌感染的淋病奈瑟菌菌株的独立特性。

Infect Immun. 1977 Mar;15(3):834-41. doi: 10.1128/iai.15.3.834-841.1977.

淋病奈瑟菌中血清抗性表型与精氨酸生物合成基因的共转化

Cotransformation of a serum resistance phenotype with genes for arginine biosynthesis in Neisseria gonorrhoeae.

作者信息

Spratt S K, Jones F, Shockley T E, Jackson J H

出版信息

Infect Immun. 1980 Jul;29(1):287-9. doi: 10.1128/iai.29.1.287-289.1980.

DOI:10.1128/iai.29.1.287-289.1980

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551111/

Abstract

Two genes (arg-3 and arp-6) marked by arginine auxotrophy and a gene (sac-2) marked by resistance to serum killing were found to be linked by cotransformation. Evidence derived from the linkage of these markers to spc (spectinomycin resistance) suggests that sac-2 may be genetically distinct from a sac gene previously described.

摘要

通过共转化发现了两个由精氨酸营养缺陷型标记的基因（arg-3和arp-6）以及一个由抗血清杀伤标记的基因（sac-2）。这些标记与spc（壮观霉素抗性）的连锁所获得的证据表明，sac-2在遗传上可能与先前描述的一个sac基因不同。