Zhu Wenqing, Liu Ye, Chen Xiaoxiao, Qian Liling, Wang Wei, Zou Leilei, Lu Yiliang, Liu Rui
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, 200031, China.
Neurosci Bull. 2025 Sep 20. doi: 10.1007/s12264-025-01510-4.
Long-term exposure to monochromatic light during early life has been shown to significantly impact the development of myopia. However, its effect on color processing in the visual cortex remains unclear. In this study, we investigated the effects of different lighting conditions on the functional organization of color representation in the visual cortical areas V1, V2, and V4 of rhesus monkeys raised under long-wave and short-wave monochromatic illumination for four years. Using cytochrome oxidase staining and intrinsic signal optical imaging, we found that the sizes, densities, and response strengths of cortical color domains in V1, V2, and V4 were consistent across illumination conditions. In addition, the cortical distances between specific hue response patches did not significantly differ among the groups. These findings suggested that long-term monochromatic illumination does not alter the spatial organization or functional properties of color domains in the visual cortex of rhesus monkeys. This research provides new insights into the resilience of the visual system's chromatic representation despite altered lighting conditions in early life.
研究表明，幼年长期暴露于单色光下会对近视的发展产生显著影响。然而，其对视觉皮层颜色处理的影响仍不清楚。在本研究中，我们调查了在长波和短波单色光照下饲养四年的恒河猴，不同光照条件对其视觉皮层区域V1、V2和V4中颜色表征功能组织的影响。通过细胞色素氧化酶染色和内在信号光学成像，我们发现，在不同光照条件下，V1、V2和V4中皮质颜色域的大小、密度和反应强度是一致的。此外，各实验组之间特定色调反应斑块之间的皮质距离没有显著差异。这些发现表明，长期单色光照不会改变恒河猴视觉皮层中颜色域的空间组织或功能特性。尽管幼年生活中的光照条件发生了变化，但这项研究为视觉系统颜色表征的恢复力提供了新的见解。
